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Xeljanz (tofacitinib) (Rheumatoid Arthritis) Forecast and Market Analysis - Product Image

Xeljanz (tofacitinib) (Rheumatoid Arthritis) Forecast and Market Analysis

  • ID: 2368656
  • November 2012
  • 51 pages
  • GlobalData

Xeljanz (tofacitinib) (Rheumatoid Arthritis) Forecast and Market Analysis

Summary

GlobalData has released its new PharmaPoint Drug Evaluation report, Xeljanz (tofacitinib) (Rheumatoid Arthritis) Forecast and Market Analysis. The RA market is currently very dynamic, with the November 6, 2012 FDA approval of Pfizer’s Xeljanz (tofacitinib) and novel oral therapies awaiting approval such as: Eli Lilly’s anti-BAFF, tabalumab and JAK1,2 inhibitor, baricitinib, and Rigel/AZ’s SYK inhibitor, fostamatinib. These compounds will challenge the current biologics in the attempt to dislodge the stronghold of the TNF inhibitors, if their safety and efficacy profiles are proven once they enter the market.

Pfizer has developed Xeljanz (tofacitinib;formerly known as tasocitinib), an oral, small-molecule inhibitor of JAK3 kinase for the treatment of RA, psoriasis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, ulcerative colitis, transplant rejection, and dry eye syndrome. Xeljanz (tofacitinib) is the most advanced kinase inhibitor in development for RA and is a first-in-class product. Xeljanz (tofacitinib) targets the JAK pathway, thus disrupting READ MORE >

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1.1 List of Tables
1.2 List of Figures
2 Introduction
2.1 Catalyst
2.2 Related Reports
3 Disease Overview
3.1 Etiology and Pathophysiology
3.1.1 Etiology
3.1.2 Pathophysiology
3.1.3 Prognosis
3.1.4 Quality of Life
3.2 Symptoms
4 Disease Management
4.1 Overview
4.2 Diagnosis
4.3 Treatment
5 Competitive Assessment
5.1 Overview
5.2 Strategic Competitor Assessment
6 Opportunity and Unmet Need
6.1 Overview
6.2 Unmet Needs
6.2.1 More rheumatologists in the field and physician knowledge of the disease
6.2.2 More cost-effective therapies through oral formulation and biosimilars
6.2.3 The development of predictive tests and discovery of biomarkers
6.2.4 The discovery of curative therapies
6.2.5 Improved drug safety and efficacy profiles
6.3 Gap Analysis
6.4 Opportunities
6.4.1 Predictive tools for diagnosis and treatment
6.4.2 Target specificity
7 Pipeline Assessment
7.1 Overview
7.2 Promising Drugs in Clinical Development
8 Xeljanz (tofacitinib)
8.1 Overview
8.2 Efficacy
8.3 Safety
8.4 Dosing and Formulation
8.5 Potential Clinical Positioning
8.6 Potential Commercial Positioning
8.7 Pricing and Reimbursement
8.8 SWOT Analysis
8.9 Forecast
9 Appendix
9.1 Abbreviations
9.2 Bibliography
9.3 Methodology
9.4 Forecasting Methodology
9.4.1 Diagnosed Rheumatoid Arthritis Patients
9.4.2 Percent Drug-treated Patients
9.4.3 General Pricing Assumptions
9.4.4 Pricing of Pipeline agents
9.5 Physicians and Specialists Included in this Study
9.6 Primary Research - Prescriber Survey
9.7 About the Authors
9.7.1 Analysts
9.7.2 Global Head of Healthcare
9.8 About Us
9.9 Contact Us
9.10 Disclaimer

1.1 List of Tables
Table 1: Symptoms of Rheumatoid Arthritis
Table 2: Treatment Guidelines for Rheumatoid Arthritis
Table 3: Top Three Biologics Prescribed for Moderate-Severe Rheumatoid Arthritis by Market
Table 4: Treatment Guidelines for Rheumatoid Arthritis
Table 5: Overall Unmet Needs - Current Level of Attainment
Table 6: Clinical Unmet Needs - Gap Analysis, 2012
Table 7: Rheumatoid Arthritis - Phase Pipeline, 2012
Table 8: Comparison of Therapeutic Classes in Development for RA, 2012
Table 9: Product Profile - Xeljanz (tofacitinib)
Table 10: Clinical Trial Locations by Country for Xeljanz (tofacitinib)
Table 11: ORAL Standard ACR 20 Responses for Xeljanz (tofacitinib) vs. Placebo vs. Humira at Month 6
Table 12: ORAL Step ACR 20, 50, 70 Responses for Xeljanz (tofacitinib) vs. Placebo at Month Six
Table 13: Efficacy Issues Regarding Xeljanz (tofacitinib) Determined by FDA Advisory Panel, May 2012
Table 14: Safety Issues Regarding Xeljanz (tofacitinib) Determined by FDA Advisory Panel, May 2012
Table 15: Xeljanz (tofacitinib) Clinical Trial Mortalities as of September 29, 2011
Table 16: Xeljanz (tofacitinib) SWOT Analysis, 2012
Table 17: Global Sales Forecasts ($m) for Xeljanz (tofacitinib)
Table 18: Physicians Surveyed, By Country

1.2 List of Figures
Figure 1: Healthy and Arthritic Joint with Rheumatoid Arthritis
Figure 2: Rheumatoid Arthritis Biologic Drug Targets
Figure 3: Diagnosis Criteria for Rheumatoid Arthritis Based on 2010 ACR/EULAR Criteria Point System
Figure 4: Severity of Rheumatoid Arthritis
Figure 5: Biologic Treatment Flow Based on Updated 2012 ACR Treatment Recommendations-
Figure 6: Competitive Assessment of Late-Stage Pipeline Agents in RA, 2012-2022

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