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qPCR and dPCR Instrumentation - Global Strategic Business Report Product Image

qPCR and dPCR Instrumentation - Global Strategic Business Report

  • Published: October 2013
  • Region: Global
  • 206 Pages
  • Global Industry Analysts, Inc

This report analyzes the worldwide markets for qPCR and dPCR Instrumentation in US$ Million. The Global market is further analyzed by the following Product Segments and End-Use Markets: Product Segments - qPCR (quantitative Polymerase Chain Reaction), and dPCR (digital Polymerase Chain Reaction); End-Use markets - Educational/Research, Testing Laboratories, and Pharma.

The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, Middle East/Africa, and Latin America. Annual estimates and forecasts are provided for the period 2009 through 2018.

Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs.

The report profiles 49 companies including many key and niche players such as:

- Agilent Technologies
- Biofire Diagnostics, Inc.
- Bio-Rad Laboratories, Inc.
- Cepheid
- Eppendorf AG
- Exiqon A/S
- F. Hoffmann-La Roche Ltd.
- Fluidigm Corporation
- Illumina, Inc.

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qPCR AND dPCR INSTRUMENTATION MCP-7856
A GLOBAL STRATEGIC BUSINESS REPORT

CONTENTS

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS
Study Reliability and Reporting Limitations
Disclaimers
Data Interpretation & Reporting Level
Quantitative Techniques & Analytics
Product Definitions and Scope Of Study
Polymerase Chain Reaction
qPCR
dPCR

II. EXECUTIVE SUMMARY

1. INDUSTRY OVERVIEW
Polymerase Chain Reaction: An Integral Part of Gene Amplification & Quantification
As Real-Time PCR Technology Matures, Saturation is Imminent Digital PCR Sales to Skyrocket in Near Term
qPCR-dPCR Adoption to Zoom in Japan
Macro-Growth Drivers
Progress in Human Genome Project and Molecular Diagnostics
Domain Spur Demand for the Gene Amplification Technologies
Prospects for Predictive Genetic Diagnostics and Testing Grow Brighter
Next-Generation Sequencing - A Giant Leap in Genome Sequencing
Increasing Incidence and Prevalence of Cancer: A Grim Reality
Driving Demand for qPCR and dPCR

2. MAJOR TRENDS & ISSUES
PCR Continues to Dominate Amplification Technologies
Cost of PCR instruments and Reagents to Decline
Advancements in Probe Technology Enhance qPCR Sensitivity
qPCR Market to Witness increasing Affinity for Automated and Robotic Equipment
Factors influencing Selection of Lab Robots
Striking the Right Balance between qPCR and dPCR in Research Laboratories
qPCR- A Suitable Tool for Gene Expression and Validation
Digital PCR Holds Potential to Take Quantification of Nucleic Acids to the Next Level
dPCR - A Valuable Tool in Virology Research
High Sensitivity Viral Detection
Creation and Validation of Viral Reference Standards
High-Precision Quantification
New dPCR Systems Threaten to Disrupt qPCR Market
Table 1: Leading dPCR Systems At a Glance
QuantStudio 3D Digital PCR System
BioMark HD system
QX100 droplet digital PCR System
RainDrop Systems
Applications of Droplet dPCR
Lab on Chip/Microfluidic RT-PCR- A Game Changer in the Offing
Two Types of Microfluidic Designs
Advantages of Lab on Chip PCR
Roadblocks in the Path to Development
New Developments in Lab-on-chip PCR
Researchers Continue to Campaign for Adoption and Strict Compliance with MIQE and SPIDIA Guidelines
Alternate Technologies Pose Threat to Growth of PCR Market
New Isothermal PCR Technology - A Potential Game Changer
Promising Faster PCR

3. COMPETITION
Competitive Landscape
Table 2: Leading Players in Global RT-PCR Instruments Market (2012): Percentage Breakdown of Value Sales for Life Sciences Research by Leading Players - Life Technologies, Bio-Rad, Roche, Agilent, Qiagen and Others (includes corresponding Graph/Chart)
Select Real-Time PCR Products by Company
Life Technologies Corporation: the Unquestioned Leader in qPCR
Table 3: Life Technologies’ Royalty Roll-Off by Year: 2009-2013 (includes corresponding Graph/Chart)
Competition Heats Up in dPCR Market
Manufacturers Step-Up Online Exposure
Multiple Factors to Sustain Consolidation Trend in PCR Industry
Staving off Competitive Pressure
Accelerated Commercialization of Products
Market Leaders Gear Up to Offer Integrated and Multi- technology Solutions
Manufacturers Target Expansion of Distribution Reach and Global Footprint

4. END-USE MARKET ANALYSIS
Application Areas of PCR
Medical and Diagnostics
PCR Plays a Vital Role in the Diagnosis of Infectious Diseases
Detection of Antimicrobial Resistance
PCR-Based Nucleic Acid Amplification for Detection of Antimicrobial Agents
Forensic and Paternity Testing
Food Safety
Detection and Quantification of Food Pathogens
Detection of Beneficial and Non-Pathogenic Microbes
Study of Microbial Responses to Environment
Microbial Risk Assessment
qPCR Application in Food Microbiology: Study of SelectMicro-Organisms By Target Gene and Food Substrate
PCR Technique in Identification of GMOs
Research & Academics
SYBR Dye and Taqman Techniques Popular in Research Publications

5. PRODUCT OVERVIEW
Introduction to Polymerase Chain Reaction
Reagents and Components Required for PCR Reaction Steps
Denaturation
Annealing
Extension
Real-Time PCR or Quantitative PCR (qPCR)
qPCR Instrumentation
Evolution
Working of qPCR Instruments
Thermal Control
Fluorimetry
DNA Detection Methods
Fluorescence Measurement
Asymmetrical dsDNA dyes
Quantification
High-Throughput qPCR
Comparison of Working of Conventional PCR versus qPCR
Drawbacks in Core PCR
Advantages of qPCR
Disadvantages of qPCR
End-Use Applications of qPCR
Factors Influencing Purchase Decisions of qPCR Systems
qPCR Consumables, Accessories and Software
Digital PCR
Development of dPCR
Working Principle
Droplet dPCR
Applications of dPCR
Advantages of dPCR

6. INSIGHT INTO GLOBAL SPENDING ON LIFE SCIENCES RESEARCH
Sequestration Bites Deep into US Research Funds
Table 4: NIH Annual Appropriations in Current and Inflation Adjusted Figures, and Total No. of Research Projects Grants (2008-2013) (includes corresponding Graph/Chart)

Table 5: NCI Research Spending in US$ Millions on Major Types of Cancers Listed in Decreasing Order of Prevalence (2010, 2011 & 2012) (includes corresponding Graph/Chart)
New MoPath Codes for Reimbursement for Medical Diagnostics Tests
Japan Falling Back in Race on Account of Economic Woes
Table 6: Human Frontier Science Program Budget for 2014 by Country: Contribution in US$ Million for Japan, United States, European Union, and Others (includes corresponding Graph/Chart)
Fiscal Prudence to Undermine Research Programs
Table 7: European Research Council (ERC) Funding for Life Sciences by Country (2008-2013): Breakdown of Number of Starting Grants Allocated for United Kingdom, Germany, France, Israel, Switzerland, Netherlands, Sweden, Spain, Belgium, Austria, and Others (includes corresponding Graph/Chart)

Table 8: European Research Council (ERC) Funding for Life Sciences by Country (2008-2013): Breakdown of Number of Advance Grants Allocated for United Kingdom, Germany, France, Switzerland, Netherlands, Italy, Israel, Spain, Sweden, Belgium, and Others (includes corresponding Graph/Chart) Asia Pacific - The New Global Hub for Life Sciences Research

7. PRODUCT INNOVATIONS/ INTRODUCTIONS
Life Technologies Launches QuantStudio 3D Digital PCR System
LGC Introduces Updated 1536-Well PCR Plate for Genomics Applications
Exiqon Unveils Toxicology Focus microRNA PCR Panel
Exiqon Introduces LNA™ LongRNA GapmeR Products
Life Technologies and Quidel Secure US FDA Approval for Marketing RT-PCR Instruments
Life Technologies Obtains US FDA Approval for 3500 Dx Genetic Analyzers and SeCore® HLA Typing Kit
Bio-Rad Unveils iTaq Universal Supermixes
Nextreme Thermal Solutions Introduces New-Generation Reference Design for Compact PCR Thermal Cycler
Sigma Life Science Introduces KiCqStart Primers
Bio-Rad Rolls Out CFX96 Touch Deep Well PCR Detection System
Roche Introduces Light Cycler 96 System
Fluidigm Rolls Out New Integrated Fluidic Circuits
Promega Unveils GoTaq Master Mixes Range
Illumina Unveils Real-Time PCR Reagent Portfolio
Integromics® Introduces OmicsOffice® Platform
Ingenuity Systems and Life Technologies Unveil Ingenuity
iReport for Real-Time PCR
Life Technologies Introduces QuantStudio™ Dx Real-Time PCR
Instrument
RainDance Technologies Introduces RainDrop™ Digital PCR Platform
Life Technologies Unveils QuantStudio 3D Digital PCR System
Chip-Based Instrument
Integromics® Unveils RealTime StatMiner® 4.3 on TIBCO® Spotfire®
Bio-Rad Laboratories Unveils CFX Qualification Plate
Bio-Rad Laboratories Introduces CFX96 Touch Deep Well™ RT-PCR
Detection System
Exiqon Unveils miRCURY™ RNA Isolation Kit-Biofluids
Bio-Rad Laboratories Launches One-Step RT-ddPCR Kit
Accelero® Bioanalytics Announces Addition of RT-qPCR System of Applied Biosystems
Roche Introduces New LightCycler® Nano Instrument in US
Life Technologies Unveils Flagship Applied Biosystems
QuantStudio™ 12K Flex Real-Time PCR system
Life Technologies Launches VetMAX™-Gold SIV Detection Real- Time PCR Kit
Life Technologies Introduces Diagnostics Platforms in Japan
Fluidigm Launches New BioMark™ HD Real-Time PCR System
Thermo Fisher Scientific Introduces Thermo Scientific PikoReal
Real-Time PCR Systems
Exiqon Introduces Focus microRNA PCR Panels
Bio-Rad Unveils New Color Touch Screens for Select Bio-Rad 1000 PCR Systems
Asuragen Introduces ARQ IS Calibrator Panels
Biometra Announces Launch of TProfessional TRIO Featuring New Thermocycler Technology
Bio-Rad Laboratories Introduces MIQE qPCR App on Apple App Store
Bio-Rad Laboratories Launches CFX Connect RT-PCR Detection System
Bio-Rad Laboratories Launches iScript Advanced cDNA Synthesis Kit
Fluidigm Introduces SNPtype Assays, DELTAgene Assays and Access Array Target-specific Primers
InstantLabs® Expands Presence in Middle East by Installing
Hunter Accelerated-PCR® Systems
Life Technologies Launches Kit for Digital PCR on OpenArray®
Real-Time qPCR System
Analytik Jena Introduces New Real-Time PCR Systems
Promega Introduces New PromegaGoTaq® 2-Step RT-qPCR Reagent System
Illumina Introduces Eco Real-Time PCR System
Life Technologies Introduces ViiA 7 Real-Time PCR System
Agilent Technologies Introduces Brilliant III Ultra-Fast QPCR and QRT-PCR Master Mix Kits
Bio-Rad Launches CFX Automation System for CFX96 and CFX384
Real-Time PCR Detection Systems

8. RECENT INDUSTRY ACTIVITY
Quotient Bioresearch Divests Bioanalytical Sciences Business to LGC
Thermo Fisher Scientific Inks Definitive Agreement to Take Over Life Technologies
QIAGEN and WaferGen Bio-systems Ink Co-Marketing Agreement
Biodesign Institute® Enters into Partnership with Life Technologies
WaferGen Bio-systems Enters into Partnership with Salk Institute to Establish nano-qPCR Core Laboratory
TATAA Biocenter Extends Product Line
Integrated DNA Technologies to Showcase Novel Multiplex qPCR Assays
Illumina and VWR International Sign Agreement
Integrated DNA Technologies Collaborates with RainDance Technologies
Life Technologies Takes Over Compendia Bioscience
Luminex Takes Over GenturaDx
Life Technologies Takes Over Pinpoint Genomics
Idaho Technology Announces Corporate Rebranding to BioFire Diagnostics
Exosome Diagnostics and Life Technologies Ink Agreement
Abbott Inks Partnership Agreement with Astellas Pharma Global
Development for Executing Clinical Trial on TransVax™ Vaccine
Accelero Bioanalytics and Synlab Clinical Trial Enter into Collaboration
Immunexpress Group, Biocartis and Debiopharm Ink Agreement to Develop and Commercialize SeptiCyte® Triage Assay
Accelero Bioanalytics Collaborates with LPT Laboratory
Bio-Rad Laboratories Takes Over QuantaLife
AlphaHelix Merges with Techtum Lab
Applied Biosystems Obtains FDA Clearance for 7500 Fast Dx
Real-Time PCR Instrument
Fluidigm Selects Research Instruments as Distributor in Thailand and Singapore
Life Technologies and Quidel Ink Agreement
Roche Applied Science and IT-IS Life Sciences Ink Worldwide Exclusive OEM Agreement
Roche Inks Co-Exclusive Distribution Contract with Lonza for Commercializing MycoTOOL Mycoplasma PCR Assays
WaferGen Biosystems Enters into Agreement with NuGEN
Technologies for Integrated Workflows for Gene Expression
Thermo Fisher Scientific Snaps up Fermentas International
Thermo Fisher Scientific Acquires Finnzymes
Illumina Acquires Helixis
Fluidigm Partners with SABiosciences

9. FOCUS ON SELECT GLOBAL PLAYERS
Agilent Technologies (US)
Biofire Diagnostics, Inc. (US)
Bio-Rad Laboratories, Inc. (US)
Cepheid (US)
Eppendorf AG (Germany)
Exiqon A/S (Denmark)
F. Hoffmann-La Roche Ltd. (Switzerland)
Fluidigm Corporation (US)
Illumina, Inc. (US)
Life Technologies Corporation (US)
Promega Corporation (US)
RainDance Technologies, Inc. (US)
QIAGEN N.V. (Netherlands)
Takara Bio, Inc. (Japan)
Thermo Fisher Scientific (US)

10. GLOBAL MARKET PERSPECTIVE
Table 9: World Recent Past, Current & Future Analysis for qPCR and dPCR Instrumentation by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific, Middle East & Africa and Latin America Markets Independently Analyzed with Annual Revenue Figures in US$ Million for the Years 2009 through 2018 (includes corresponding Graph/Chart)

Table 10: World 10-Year Perspective for qPCR and dPCR Instrumentation by Geographic Region - Percentage Breakdown of Revenues for US, Canada, Japan, Europe, Asia-Pacific, Middle East & Africa and Latin America Markets for the Years 2009, 2013 & 2018 (includes corresponding Graph/Chart)

Table 11: World Recent Past, Current & Future Analysis for qPCR and dPCR Instrumentation by Product Segment - qPCR and dPCR Markets Independently Analyzed with Annual Revenue Figures in US$ Million for the Years 2009 through 2018 (includes corresponding Graph/Chart)

Table 12: World 10-Year Perspective for qPCR and dPCR Instrumentation by Product Segment - Percentage Breakdown of Revenues for qPCR and dPCR Markets for the Years 2009, 2013 & 2018 (includes corresponding Graph/Chart)

Table 13: World Recent Past, Current & Future Analysis for qPCR and dPCR Instrumentation by End-Use Segment - Educational/Research, Testing Laboratories and Pharma Markets Independently Analyzed with Annual Revenue Figures in US$ Million for the Years 2009 through 2018 (includes corresponding Graph/Chart)

Table 14: World 10-Year Perspective for qPCR and dPCR Instrumentation by End-Use Segment - Percentage Breakdown of Revenues for Educational/Research, Testing Laboratories and Pharma Markets for the Years 2009, 2013 & 2018 (includes corresponding Graph/Chart)

III. MARKET

1. THE UNITED STATES
A.Market Analysis
Current and Future Analysis
Real-Time PCR Market in North America: A Primer
Key Factors (Ranked in Order) in Buyer Selection of Real-Time/qPCR Platforms
qPCR and dPCR Instrumentation in the US: An Overview
Competition
Product Launches
Strategic Corporate Developments
Key Players
B.Market Analytics
Table 15: US Recent Past, Current & Future Analysis for qPCR and dPCR Instrumentation Market Analyzed with Annual Revenue Figures in US$ Million for the Years 2009 through 2018 (includes corresponding Graph/Chart)

2. CANADA
A.Market Analysis
Current and Future Analysis
Strategic Corporate Development
Funglyn biotech, inc. - a key player
B.Market Analytics
Table 16: Canadian Recent Past, Current & Future Analysis for qPCR and dPCR Instrumentation Market Analyzed with Annual Revenue Figures in US$ Million for the Years 2009 through 2018 (includes corresponding Graph/Chart)

3. JAPAN
A.Market Analysis
Current and Future Analysis
Product Launch
Strategic Corporate Development
Takara bio, inc. - a key player
B.Market Analytics
Table 17: Japanese Recent Past, Current & Future Analysis for qPCR and dPCR Instrumentation Market Analyzed with Annual Revenue Figures in US$ Million for the Years 2009 through 2018 (includes corresponding Graph/Chart)

4. EUROPE
A.Market Analysis
Current and Future Analysis
PCR Reagents in Europe: An Overview
Product Launches
Strategic Corporate Development
B.Market Analytics
Table 18: European Recent Past, Current & Future Analysis for qPCR and dPCR Instrumentation by Geographic Region - France, Germany, Italy, UK, and Rest of Europe Markets Independently Analyzed with Annual Revenue Figures in US$ Million for the Years 2009 through 2018 (includes corresponding Graph/Chart)

Table 19: European 10-Year Perspective for qPCR and dPCR Instrumentation by Geographic Region - Percentage Breakdown of Revenues for France, Germany, Italy, UK, and Rest of Europe Markets for the Years 2009, 2013 & 2018 (includes corresponding Graph/Chart)

4a. FRANCE
A.Market Analysis
Current and Future Analysis
B.Market Analytics
Table 20: French Recent Past, Current & Future Analysis for qPCR and dPCR Instrumentation Market Analyzed with Annual Revenue Figures in US$ Million for the Years 2009 through 2018 (includes corresponding Graph/Chart)

4b. GERMANY
A.Market Analysis
Current and Future Analysis
Product Launches
Strategic Corporate Developments
Eppendorf Ag - A Key Player
B.Market Analytics
Table 21: German Recent Past, Current & Future Analysis for qPCR and dPCR Instrumentation Market Analyzed with Annual Revenue Figures in US$ Million for the Years 2009 through 2018 (includes corresponding Graph/Chart)

4c. ITALY
A.Market Analysis
Current and Future Analysis
B.Market Analytics
Table 22: Italian Recent Past, Current & Future Analysis for qPCR and dPCR Instrumentation Market Analyzed with Annual Revenue Figures in US$ Million for the Years 2009 through 2018 (includes corresponding Graph/Chart)

4d. THE UNITED KINGDOM
A.Market Analysis
Current and Future Analysis
Strategic Corporate Development
B.Market Analytics
Table 23: UK Recent Past, Current & Future Analysis for qPCR and dPCR Instrumentation Market Analyzed with Annual Revenue Figures in US$ Million for the Years 2009 through 2018 (includes corresponding Graph/Chart)

4e. REST OF EUROPE
A.Market Analysis
Current and Future Analysis
Product Launches
Strategic Corporate Developments
Key Players
B.Market Analytics
Table 24: Rest of Europe Recent Past, Current & Future Analysis for qPCR and dPCR Instrumentation Market Analyzed with Annual Revenue Figures in US$ Million for the Years 2009 through 2018 (includes corresponding Graph/Chart)

5. ASIA-PACIFIC
A.Market Analysis
Current and Future Analysis
B.Market Analytics
Table 25: Asia-Pacific Recent Past, Current & Future Analysis for qPCR and dPCR Instrumentation by Geographic Region - China and Rest of Asia-Pacific Markets Independently Analyzed with Annual Revenue Figures in US$ Million for the Years 2009 through 2018 (includes corresponding Graph/Chart)

Table 26: Asia-Pacific 10-Year Perspective for qPCR and dPCR Instrumentation by Geographic Region - Percentage Breakdown of Revenues for China and Rest of Asia-Pacific Markets for the Years 2009, 2013 & 2018 (includes corresponding Graph/Chart)

5a. CHINA
A.Market Analysis
Current and Future Analysis
B.Market Analytics
Table 27: Chinese Recent Past, Current & Future Analysis for qPCR and dPCR Instrumentation Market Analyzed with Annual Revenue Figures in US$ Million for the Years 2009 through 2018 (includes corresponding Graph/Chart)

5b. REST OF ASIA-PACIFIC
A.Market Analysis
Current and Future Analysis
Professional Biotech Pvt. Ltd. - A Key Real Time PCR
Manufacturer in India
B.Market Analytics
Table 28: Rest of Asia-Pacific Recent Past, Current & Future Analysis for qPCR and dPCR Instrumentation Market Analyzed with Annual Revenue Figures in US$ Million for the Years 2009 through 2018 (includes corresponding Graph/Chart)

6. MIDDLE EAST & AFRICA
A.Market Analysis
Current and Future Analysis
Product Launch
B.Market Analytics
Table 29: Middle East & Africa Recent Past, Current & Future Analysis for qPCR and dPCR Instrumentation Market Analyzed with Annual Revenue Figures in US$ Million for the Years 2009 through 2018 (includes corresponding Graph/Chart)

7. LATIN AMERICA
A.Market Analysis
Current and Future Analysis
B.Market Analytics
Table 30: Latin American Recent Past, Current & Future Analysis for qPCR and dPCR Instrumentation Market Analyzed with Annual Revenue Figures in US$ Million for the Years 2009 through 2018 (includes corresponding Graph/Chart)

IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 49 (including Divisions/Subsidiaries - 51)

The United States (29)
Canada (1)
Japan (1)
Europe (19)
- Germany (7)
- The United Kingdom (2)
- Spain (1)
- Rest of Europe (9)
Asia-Pacific (Excluding Japan) (1)

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