Jain PharmaBiotech, Feb 2012, Pages: 639
in cancer drug delivery
2. Innovative treatments for cancer
Introduction
Selective estrogen receptor modulators
Antiangiogenic strategies for cancer
Development of antiangiogenic therapies
Jain PharmaBiotech, Feb 2012, Pages: 276
modulators are described and compared along with developmental status. NO-related mechanisms of action in existing drugs are identified.
Various pharmacological approaches are described along
Spectra Intelligence, Nov 2006, Pages: 367
. Important themes covered in this chapter include rational drug design approaches, recombinant DNA technologies applied to drugdiscovery, and tumour-targeted approaches. Taken together, these therapeutic
BioPharm Reports (VennBio Ltd.), Jan 2009, Pages: 235
includes proposed resistance mechanisms associated with CSCs, drugdiscoverystrategies for the targeting of these cells, the current CSC-targeting drug development pipeline and the potential of these cells
Jain PharmaBiotech, Feb 2012, Pages: 1008
is replacing the old fashioned bone marrow transplants. Role of cells in drugdiscovery is also described. Cell therapy is bound to become a part of medical practice.
Stem cells are discussed in detail in one
Jain PharmaBiotech, Feb 2012, Pages: 485
RNAs for anticancer drugdiscovery
siRNAs for inducing cancer immunity
siRNAs for inhibition of angiogenesis
siRNA targeting the R2 subunit of ribonucleotide reductase
siRNA for cancer chemoprevention
siHybrids vs
Datamonitor, April 2010, Pages: 243
with greater efficacy
Small molecules
Small molecules targeting tyrosine kinases have been a significant development in oncology drugdiscovery
Classification of pipeline products
Angiogenesis inhibitor
Global Industry Analysts, Inc., Oct 2011, Pages: 897
Inhibitors 32
Angiogenesis Inhibitors 32
List of Approved Angiogenesis Inhibitors 32
Proteasome Inhibitors 32
Multi-Targeted Drugs 32
Select Approved Multi-Targeted Drugs in Targeted Cancer
Therapy 33
Bioseeker, Sep 2007, Pages: 500
oncology areas; Breast- and Prostate cancer. And provide a framework but also a careful identification and evaluation of drug candidates, technologies and competitors.
Decoding Big Pharma’s R&D Strategy
Lead Discovery, May 2005
is targeted at all involved in drug development extending from preclinical drugdiscovery personnel to business development managers and strategists.
Summary of key issues & conclusions
- The field of HDAC
Informa Healthcare, Jan 2006, Pages: 170
generally target key
signaling molecules/pathways associated with cancer development. These include drugs that target growth factor receptors (e.g. the EGF or IGF receptor), angiogenesis, farnesylation
Bioseeker, Dec 2005
-angiogenesis
Box 7: New Target - EGF Like Domain
Box 8: Kinesin Development Patents
Box 9: Competitive Patents to those of Adherix
Box 10: Important Targets in Cancer DrugDiscovery
Box 11: DS Modelling
Lead Discovery, Jan 2003, Pages: 65
is now CEO and chief analyst at LeadDiscovery and coordinates the identification of candidate drugdiscovery projects with industrial potential. Background
Apoptosis
A general introduction to apoptosis
Elsevier Science and Technology, Sep 1997, Pages: 65
and fibrates. 40. Cardiovascular new drugdiscovery of the future: molecules, genes and machines. 41. The action of serpins and heparin as leads in drugdiscovery. 42. Inverse isostere strategies