John Wiley and Sons Ltd, Oct 2008, Pages: 422
Toxicogenomics: A Powerful Tool For Toxicity Testing provides up-to-date state-of-the-art information presented by the recognized experts, and is therefore an authoritative source of current
John Wiley and Sons Ltd, July 2011, Pages: 396
This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed
Elsevier Science and Technology, July 2008, Pages: 352
Toxicogenomics analyses the activity of a particular toxin or chemical substance on living tissue based upon a profiling of its known effects on genetic material. Toxicogenomics is important because
Informa Healthcare, March 2003, Pages: 348
, toxicogenomics is a fast-rising star within toxicological analysis.
Gathering together leading authors and scientists at the forefront of the field, An Introduction to Toxicogenomics provides a comprehensive
Informa Healthcare, Oct 2008, Pages: 432
that focus mainly on toxicogenomic techniques, Genomics presents a thorough overview of the field in four major sections: 1) fundamentals of genes and genome structure, function, expression, variations
John Wiley and Sons Ltd, Nov 2008, Pages: 480
, and toxicogenomics toolbox. The authors provide a valuable resource for pharmaceutical discovery scientists, preclinical drug safety department personnel, regulatory personnel, discovery toxicologists, and safety
Business Insights, April 2009, Pages: 159
technologies for predictive safety testing
Summary
Introduction
Toxicogenomics and systems biology
Commercial platforms
Cell-based assays
Stem cells
Conclusions
Chapter 4 Novel in vivo methods
John Wiley and Sons Ltd, Jan 2011, Pages: 1040
Contributors ix
Preface xvii
Acknowledgments xix
Abbreviations and Acronyms xxi
Part One - Toxicogenomics
1 Toxicogenomics: An Overview with Special Reference to Genetic and Genomic Approaches
John Wiley and Sons Ltd, Jan 2010, Pages: 565
theoretical and practical aspects of pharmaceutical data mining, focusing on diverse approaches for drug discovery—including chemogenomics, toxicogenomics, and individual drug response prediction. The five main
Informa Healthcare, March 2006, Pages: 416
, toxicogenomics, and metabonomics, this expertly conceived guide explores toxicological issues of particular world interest, such as toxicity of nanomaterials, military jet fuels, and genetically-modified foods
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. The Influence of Regulation on Toxicology. National Toxicology Program. Influence of Toxicological Research on the Regulatory Process. Toxicogenomics and Regulatory Science. Physiological based Pharmacokinetics
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case study
Limitations of metabonomics
Conclusions
Chapter 4 Biomarkers aiding go/no go decisions
Summary
Introduction
Technologies for safety biomarker discovery
Toxicogenomics
Genomic
John Wiley and Sons Ltd, Sep 2009, Pages: 373
to:
- Identify and validate new drug candidates
- Enhance transcriptional profiling to better find and validate biomarkers
- Assess toxicology
- Employ toxicogenomics to identify genes relevant
Business Insights, June 2010, Pages: 250
in drug discovery for malaria
Using in silico tools in HIV drug discovery
High content cellular imaging in infectious diseases
Application to bacterial diseases
Toxicogenomics-based assays in infectious
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& Monitoring of patient data during clinical trials, Proteomics, Toxicogenomics, Microbial Genotyping, Agricultural Biology, and Environmental Control
On the basis of types:
Oligonucleotide DNA Microarrays (o
Elsevier Science and Technology, April 2012, Pages: 1248
materials, FDA regulatory issues, and ethics in veterinary toxicology.
- New chapters covering important and timely topics such as melamine and cyanuric acid, toxicogenomics, toxic gases and veterinary
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, toxicogenomics, genomics, drug discovery, and others.
On the basis of types:
- DNA microarrays, lab on chip, protein microarrays, other arrays (cell arrays and tissue arrays)
On the basis of geography
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and Validation of Toxicologic Biomarkers. Use of Biomarkers in Occupational Safety and Health. Toxicogenomic and Toxicoproteomic Approaches for Biomarkers. Biomarkers of Chemical Warfare Agent Exposure
John Wiley and Sons Ltd, May 2010, Pages: 472
of Sex Determination in Domestic Animals (Eric Pailhoux and Corinne Cotinot, Batiment J. Poly).
Chapter 17. Toxicogenomics of Reproductive Endocrine Disruption (Ulf Magnusson and Lennart Dencker, Swedish
