Volume 4 describes work on the modification of DNA by AT specific anticancer drugs, DNA alkylation events which involve metabolite generation, DNA sequence recognition by two selective binders, bulged DNA microenvironments as molecular targets, DNA sequence specific binding by short peptides and the analysis of DNA-protein interactions using DNase I footprinting methodology.
. Expert contributors from the Biomedical world
. Emerging areas of drug design and therapeutic applications
. Nucleic acid-protein interactions
. Color graphics of molecular modeling analyses
. New and emerging methodologies
2. DNA-alkylating events associated nitrogen mustard based anticancer drugs and the metabolic byproduct acrolein (M.E. Colvin, J.N. Quong).
3. Molecular basis for recognition and binding of specific DNA sequences by calicheamicin and duocarmycin (G. Bifulco, et al.).
4. Enediyne antibiotic neocarzinostatin as a radical-bsed probe of bulged structures in nucleic acids (Zhen Xi, I.H. Goldberg).
5. Sequence-specific DNA binding by short peptides (T. Morii, K. Makino).
6. Equilibrium and kinetic quantitative DNAse I footprinting (G.M. Dhavan, A.K.M.M. Mollah, M. Brenowitz).