Stepping ahead of the general front, Volume 41 in the series Advances in Enzyme Regulation moves the studies of mammalian enzymic and metabolic regulation forward.
This volume was dedicated on the centenary of his birth to Sir Hans A. Krebs who gave the Special Symposium lectures for 15 years. George Weber spoke on the joint work he carried out in Oxford with Krebs and his associates, entitled "Cancer and Clinical Targeting."
Much of the Symposium centered on novel aspects of signal transduction, including Inositol Signaling and on phosphatidylinositol 3'kinase and kinase B. The Special Symposium Lecture was given on Inositol Lipid Signaling in the Nucleus.
The location and regulation of protein kinases were discussed.
Clinical aspects of enzyme regulation were presented featuring studies on dihydrophyrimidine dehydrogenase, development, citrullinemia and human melanoma heparanase.
Drug targeting and resistance were reviewed featuring etoposide and tumor vasculature. Regulation of pyruvate dehydrogenase kinase and abrogration of cytokine-dependency were analyzed. Challenging results on mRNA stability and apoptosis were presented covering cyclooxygenase-2 inhibitors, lysosomal cathepsins, human breast tumors and actin reorganization. The contents listed below provide a complete overview of topics and speakers.
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List of Participants.
Session I Signal Transduction in Cancer Cells.
Sir Hans A. Krebs centenary lecture: cancer and clinical targeting (G. Weber).
Genetic alterations at the nuclear localization signal of the RB2/p130 gene occur in lymphoid tumor but not in osteosarcoma cell lines (N.M. Maraldi).
Session II Regulation of Functions through Lipid Signaling.
An expanded view of inositol signaling (J.D. York).
Regulation of protein synthesis in the heart (F.H. Pham).
Session III Regulation through Protein Kinases.
Spontaneous occurrence of an inhibitor of protein kinase localization in a thyroid cancer cell line: role in thyroid tumorigenesis (D. Mochly-Rosen).
Regulation and role of the atypical PKC isoforms in cell survival during tumor transformation (J. Moscat).
The protein kinase activity modulation sites: mechanisms for cellular regulation
targets for the therapeutic intervention (R.A. Engh, D. Bossemeyer).
Session IV Enzymic Regulation and Pharmacology.
Importance of dihydropyrimidine dehydrogenase (DPD) deficiency in patients exhibiting toxicity following treatment with 5-fluorouracil (M.R. Johnson, R.B. Diasio).
Regulation of retinoic acid metabolism (M. Petkovich).
Session V Drug Targeting and Resistance.
Comparison of the properties of human breast cancer cells: MCF-7 and MCF-7 cells selected for resistance to etoposide (J.G. Cory).
The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting (H. Maeda).
Session VI mRNA Stability and Regulation of Apoptosis.
Adipocyte expression of a neuronal RNA binding protein (C. Qi, P.H. Pekala).
Apoptosis signaling pathways mediated by cyclooxygenase-2 inhibitors in prostate cancer cells (A.J. Johnson, C.-S. Chen).
Novel procaspase-3 activating cascade mediated by lysoapoptases and its biological significances in apoptosis (N. Katunuma).
Session VII Degradative Enzymes and Transformation.
Effect of malignant transformation on lactate levels of human mammary epithelial cells (E.O. Aboagye).
The RAS-RAF relationship: an unfinished puzzle (E. Kerkhoff, U. Rapp).
Session VIII Transformation and Kinases.
Control of pyruvate dehydrogenase kinase gene expression (R.A. Harris).
Synergistic effects of PI3K/AKT on abrogation of cytokine-dependency induced by oncogenic RAF (J.A. McCubrey).
Session IX Enzyme Regulation and Disease.
Pathogenesis of adult-onset type II citrullinemia caused by deficiency of citrin, a mitochondrial solute carrier protein: tissue and subcellular localization of citrin (M. Iijima, T. Saheki).
Human heparanase: a molecular determinant of brain metastasis (D. Marchetti).
Session X Special Symposium Lecture: Lucio Cocco.
Nuclear inositol lipid signaling (L. Cocco).