Angiogenesis: In Vitro Systems, Vol 443. Methods in Enzymology

  • ID: 1756984
  • Book
  • 432 Pages
  • Elsevier Science and Technology
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Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over antiogenesis. Diseases that are angiogensis-dependent result when blood vessels either grow excessively or insufficiently.

* Tried-and-tested techniques written by researchers that developed them, used them, and brought them to fruition

* Provides the "builder's manual" for essential techniques--a one-stop shop that eliminates needless searching among untested techniques

* Includes step-by-step methods for understanding the cell and molecular basis of wound healing, vascular integrin signaling, mechanical signaling in blood vessels, and vascular proteomics
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Studying cell signaling pathways; Flow mediated signaling; Endothelial cell adhesion and migration on the ECM; EC sprouting assays; Lumen formation assays; Isolation and propagation of EC's or SMC's; Cell-based assays to screen anti-angiogenic agents (chemical approach; ES cell models of vascular network formation; Co-culture studies with EC plus other cell types; Aortic ring sprouting (multiple cell types present); Effects of hypoxia or hyperoxia; Vascular Proteomics; In vitro vascular barrier function; EC leukocyte interactions; ECM signaling to the vasculature; Vascular Integrin signaling; Mechanical Signaling in blood vessels; Vascular and neuronal patterning; Vascular growth factors and their signals; VEGF receptor signal transduction; Development and testing of monoclonal antibodies directed to angiogenic targets.

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Cheresh, David A.
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