How does a bacterial cell grow during the division cycle? This question is answered by the codeveloper of the Cooper-Helmstetter model of DNA replication. In a unique analysis of the bacterial division cycle, Cooper considers the major cell categories (cytoplasm, DNA, and cell surface) and presents a lucid description of bacterial growth during the division cycle.
The concepts of bacterial physiology from Ole Maaløe's Copenhagen school are presented throughout the book and are applied to such topics as the origin of variability, the pattern of DNA segregation, and the principles underlying growth transitions.
The results of research on E. coli are used to explain the division cycles of Caulobacter, Bacilli, Streptococci, and eukaryotes. Insightful reanalysis highlights significant similarities between these cells and E.coli.
With over 25 years of experience in the study of the bacterial division cycle, Cooper has synthesized his ideas and research into an exciting presentation. He manages to write a comprehensive volume that will be of great interest to microbiologists, cell physiologists, cell and molecular biologists, researchers in cell-cycle studies, and mathematicians and engineering scientists interested in modeling cell growth.
- Written by one of the codiscoverers of the Cooper-Helmstetter model
- Applies the results of research on E. coli to other groups, including Caulobacter, Bacilli, Streptococci, and eukaryotes; the Caulobacter reanalysis highlights significant similarities with the E. coli system
- Presents a unified description of the bacterial division cycle with relevance to eukaryotic systems
- Addresses the concepts of the Copenhagen School in a new and original way
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A General Model of the Bacterial Division Cycle
Experimental Analysis of the Bacterial Division Cycle
Cytoplasm Synthesis during the Division Cycle
DNA Replication during the Bacterial Division Cycle
Synthesis of the Cell Surface during the Division Cycle
Density and Turgor during the Division Cycle
Variability of the Division Cycle
The Segregation of DNA and the Cell Surface
Transitions and the Bacterial Life Cycle
The Division Cycle of Caulobacter crescentus
Growth and Division of Streptococcus
Growth and Division of Bacillus
The Growth Law and Other Topics
The Eukaryotic Division Cycle
Conservation Laws of the Division Cycle