The objective of the Biotechnology Annual Review series is to attempt to provide readers with the needed indepth knowledge, by reviewing specific topics in biotechnology in each issue. The philosophy behind this series is to encourage good reviews to make it easier for readers to keep in touch with progress and applications of biotechnology. Reviews on topics related to regulatory affairs, social impact of biotechnology, biodiversity, biosafety, public acceptance and patent issues are also encouraged.
Drafts of the human genome were published in Science and Nature magazines, last year. The human genome as well as the other completed genomes can now be searched using different databases.
The exponential increase of the sequence data lead to the development of the new "Bioinformatics" field in order to attempt making sense, at least biological sense, out of all the new and fast data.
It will take also other techniques such as "functional genomics" to link the gap between a specific phenotype or a treatment and a gene sequence. Functional genomics tools are therefore important for the accurate molecular diagnosis/prognosis, target discovery and validation needed for drug development and novel targets for antibiotics development. Functional Genomics are also important for the confirmation of therapy in pharmacogenomics studies. Applications of functional genomics techniques are equally important for progress in biotechnology applications of plants, animals and other organisms.
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(T.K. Attwood, C.J. Miller). Protein formulation and fill-finish operations (S.Y. Patro, E. Freund, B.S. Chang). New chips for molecular biology and diagnostics (N. Zammatteo et al.).
Folate receptor-targeted liposomes as vectors for therapeutic agents (M.A. Gosselin, R.J. Lee). Development of vasculature targeting strategies for the treatment of cancer
and chronic inflammatory diseases (A.J. Schraa et al.). Separation of biosynthetic polyunsaturated fatty acid (PUFA) with
supercritical fluid (W. Li, M.Sivakumar). Overview of solid state bioprocessing (D.A. Mitchell, M. Berovic, N. Krieger). Antibiotics (V. Bðhal). Index of authors. Keyword index.