In 1993, Rolf Bodmer described a gene he named tinman that was required for the formation of the dorsal aorta of the fly. Flies without a functional tinman gene had no heart. Quickly, mammalian counterparts of the tinman gene were identified and found to be expressed by early cardiomyogenic precursors and by cardiomyocytes throughout heart development. Since then, significant progress has been made in the understanding of molecular and genetic determinants of heart formation. An ever growing number of genes have been identified that are required for cardiogenesis, as evidenced by severe abnormalities in cardiac development produced by inactivation in the mouse or inhibition of gene function in other model organisms.
Cardiovascular Development covers some of the latest research in the study of heart formation. Volume Editor Rolf Bodmer has assembled a world-class list of contributors whose research uses a variety of animal models and whose findings are certain to enhance our understanding of this exciting field.
* Ties together the development of heart morphology and conduction system
* The latest developments in vertebrate and invertebrate genetic model systems
* Technological advancements in cardiovascular science
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2. Morphogenesis of the Vertebrate Heart
3. Heart Development and T-box Transcription Factors: Lessons from Avian Embryos
4. Transcriptional Control of Cardiac Boundary Formation
5. Signaling Pathways in Embryonic Heart Induction
6. Islet1 Progenitors in Developing and Postnatal Heart
7. Role of MicroRNAs in Cardiovascular Biology
8. Divergent Roles of Hedgehog and Fibroblast Growth Factor Signaling in Left-Right Development
9. Development of the conduction system: Picking up the pace
10. Transcriptional Control of the Cardiac Conduction System
11. Genetic dissection of hematopoiesis using Drosophila as a model system
12. Vascular Development in the Zebrafish
13. Development and function of the epicardium
14. Genetics of transcription factor mutations
15. Human genetics of congenital heart disease