Comparative Toxicogenomics, Vol 2. Advances in Experimental Biology

  • ID: 1758650
  • Book
  • 352 Pages
  • Elsevier Science and Technology
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Functional genomics has come of age. No longer is it an adventure for the avant garde scientist, but it has become an increasingly standardized mainstream tool accessible to any modern biological laboratory. Toxicogenomics studies are now generating an avalanche of data that, with the aid of established informatics methodology, is being translated into biologically meaningful information.

This is enabling us to start harvesting the benefits from years of investment in terms of technology, time, and (of course) money. It is therefore timely to bring together leading toxicologists with a wide variety of scientific aims in this book to demonstrate how microarray technology can be successfully applied to different research areas. This book transects biology from bacteria to human, from ecologically relevant sentinel organisms to well-characterized model species, and represents the full toxicogenomics arena from exploratory "blue sky" science to the prospects for incorporation into regulatory frameworks.

* Reviews some of the first really fruitful studies made in this area
* Covers different organisms ranging from humans to model species and environmental sentinels
* Provides a broad view of the area, increasing its attractiveness to researchers working in a variety of specialties

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Joseph R. Shaw, Dartmouth College: 'Daphnia Toxicogenomics'

Professor Joseph Lunec and Dr. Eugene Halligan, King's College London: 'Human Toxicogenomics'

Jake Bundy and Jeremy Nicholson, Imperial College: "Metabolomics and Toxicogenomics"

Chris Vulpe, University of California, Berkely: "Model Organisms of Environmental Toxicogenomics (Ecotoxicological model species
Daphnia, fathead minnow and zebrafish)"

David Spurgeon, CEH Monks Wood: "Non-model organism Toxicogenomics or Earthworm Toxicogenomics"

Charles Tyler, Exeter: "Application of Toxicogenomics for study of endocrine disruption in fish"

Jason Snape, Astra-Zeneca Brixham Enviornmental Laboratories: "Microbial Toxicogenomics"

Jonathan Freedman, NIEHS: "Comparative Toxicogenomics"
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Hogstrand, Christer.
Kille, Pete.

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