- Complement regulators--structure, functional roles and mode of action- Comprehensive reviews of each of the individual regulators- Roles of Complement regulators in vivo,in health and disease: - Consequences of deficiency- Roles in the reproductive system- Interactions with pathogens- Exploitation for therapy- Complement regulators in other species
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Activation of C.
Physiological Roles of C.
Involvement of C in Pathology.
Why a Book on C Regulators?
Regulation in the Complement System:
Control of Activation Pathways.
Control in the Membrane Attack Pathway.
Control of the Anaphylactic Peptides.
Regulation in the Activation Pathways:
Regulation of C1.
Regulators Encoded in the RCA Gene Cluster.
Other Regulators of the Activation Pathways.
Regulation in the Terminal Pathway:
Fluid-Phase Regulators of the Terminal Pathway.
Membrane Regulators of the Terminal Pathway.
Recovery from C Membrane Attack.
Deficiencies of Complement Regulators:
Introduction, Deficiency of C1 Inhibitor (C1inh).
Deficiencies of Fluid-Phase C3 Convertase Regulators.
Deficiencies of Fluid-Phase Membrane Attack Pathway Regulators.
Deficiencies of Membrane Regulators of C.
Complement Regulation in the Reproductive System:
Role of C Inhibitors in the Protection of Sperm.
Role of C Regulators in Protection of the Fetus.
The Role of MCP in Fertilization.
Complement Regulators and Micro-Organisms:
Complement Regulators as Receptors for Microorgansims.
Hijacking of Complement Regulators by Microorganisms.
Complement Regulatory Proteins in Other Species:
Regulators of the Activation pathways.
Regulators of the Terminal Pathway.
Manipulation of Membrane C Regulators In Vivo.
Complement Regulators in Therapy:
Therapy with Soluble C Regulators.
Antibodies Against C Components as Therapeutics.
Complement Regulators in Xenotransplantation.
Anti-CRP Antibodies and Therapy.
Harris, Andrew L.
Dr. Harris is in the Complement Biology Group, Department of Medical Biochemistry, University of Wales College of Medicine. Her Ph.D. degree was in Professor Peter Lachmann's unit in Cambridge where, under the supervision of Dr. Richard Harrison, she undertook studies of the biochemistry of C3. She completed her Ph.D. in 1993. She retains a strong interest in the biochemical aspects of the complement system and in the regulators which control complement at the level of C3.