Constitutive Activity in Receptors and Other Proteins, Part B, Vol 485. Methods in Enzymology

  • ID: 1758967
  • Book
  • 708 Pages
  • Elsevier Science and Technology
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This volume of Methods in Enzymology covers the current methodology for the detection and assessment of constitutively active proteins. The chapters written by expert authors who are leaders in the field, provide hints and tricks not available in primary research publications.It is extensively referenced, with useful figures and tables throughout the volume.

  • Expert authors who are leaders in the field
  • Extensively referenced and useful figures and tables
  • Provides hints and tricks to facilitate reproduction of methods
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- Identification and characterization of Steroidogenic Factor-1 inverse agonists.

Mabrouka Doghman, Franck Madoux, Peter Hodder, and Enzo Lalli

- Assessment of inverse agonism for the angiotensin II type 1 receptor

Hiroshi Akazawa, Noritaka Yasuda, Shin-ichiro Miura, Issei Komuro

- Measurement of inverse agonism in BARs

Carlos Alberto Taira

- Inverse agonism of antidepressants: in vitro and in vivo studies

Joel Bockaert

- Differential inverse agonism at the human muscarinic M3 receptor

Paola Casarosa

- Ghrelin Receptor: High Constitutive Activity and Methods for Developing Inverse Agonists.

Constance Chollet

- Constitutive activity and inverse agonism at the ?1a and ?1b adrenergic receptor subtypes.

Susanna. Cotecchia

- Measurement of inverse agonism of the cannabinoid receptor

Tung Fong

- Constitutively Active Thyrotropin (TSH) and Thyrotropin-Releasing Hormone (TRH) Receptors and Their Inverse Agonists

Marvin C. Gershengorn

- Inverse retinoid agonists and neutral antagonists

Hinrich Gronemeyer

- ?-Aminobutyric Acid Type A (GABAA) Receptor Subtype Inverse Agonists as Therapeutic Agents in Cognition

Gabriella Guerrini and Ciciani Giovanna

- Assays for inverse agonists in the visual system.

Masahiro Kono

- Receptor-driven identification of novel human A3 adenosine receptor antagonists as potential therapeutic agents

Silvia Paoletta, Stephanie Federico, Giampiero Spalluto and Stefano Moro

- Inverse agonists of steroidogenic factor SF-1

Fabrice Piu and Andria L. Del Tredici

- Methods to Measure G Protein Coupled Receptor Activity for the Identification of Inverse Agonists

Gabriel Barreda-Gómez, M.Teresa Giralt and Rafael Rodríguez-Puertas

Section II-- Novel Strategies and Techniques for Constitutive Activity and Inverse Agonism

- Use of Pharmacoperones to Reveal GPCR Structural Components Associated with Receptor Activation and Trafficking

Jo Ann Janovick and P. Michael Conn

- Application of large-scale transiently transfected cells to functional assays of ion channels and other proteins.

Jun Chen, Sujatha Gopalakrishnan, Marc R Lake, and Bruce R Bianchi

- Quantification of RNA Editing of the Serotonin 2C Receptor (5-HT2CR) Ex Vivo

Maria Fe Lanfranco, Noelle C. Anastasio, Patricia K. Seitz, and Kathryn A. Cunningham

- Strategies for isolating constitutively-active and dominant-negative pheromone receptor mutants in yeast.

Mercedes Dosil and James B. Konopka

- Development of a GPR23 Cell-based ?-Lactamase Reporter Assay

Paul H. Lee and Bonnie J. Hanson

- Computational Modeling of Constitutively Active Mutants of GPCRs: C5a Receptor.

Gregory V. Nikiforovich and Thomas J. Baranski

- TSH receptor monoclonal antibodies with agonist, antagonist and inverse agonist activities

Jane Sanders, Ricardo Núñez Miguel, Jadwiga Furmaniak, Bernard Rees Smith

- Current standards, variations and pitfalls for the determination of constitutive TSHR activity in vitro

Sandra Mueller, Holger Jaeschke, Ralf Paschke

- Towards the Rational Design of Constitutively Active KCa3.1 Mutant Channels

Line Garneau, Hélène Klein, Lucie Parent, Rémy Sauvé

- Fusion proteins as model systems for the analysis of constitutive GPCR activity

Erich H. Schneider, Roland Seifert

- Screening for Novel Constitutively Active CXCR2 Mutants and Their Cellular Effects

Giljun Park, Tom Masi, Chang K. Choi, Heejung Kim, Jeffrey M. Becker, and Tim E. Sparer

- A method for parallel solid-phase synthesis of iodinated analogues of the cannabinoid receptor type I (CB1) inverse agonist rimonabant

Alan C. Spivey and Chih-Chung Tseng

- Coexpression systems as models for the analysis of constitutive GPCR activity

Roland Seifert and Erich H. Schneider

- Modelling and simulation of inverse agonism dynamics

Lloyd J. Bridge

- Design and Use of Constitutively Active STAT5 Constructs

Michael A. Farrar

- In vitro and in vivo assays of protein kinase CK2 activity

Renaud Prudent, Céline F. Sautel, Virginie Moucadel, Béatrice Laudet, Odilhe Filhol, and Claude Cochet
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Simon, Melvin I.

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