Development of the Nervous System presents a broad and basic treatment of the established and evolving principles of neural development as exemplified by key experiments and observations from past and recent times. The text is organized ontogenically. It begins with the emergence of the neural primordium and takes a chapter-by-chapter approach in succeeding events in neural development: patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, neuron survival and death, synapse formation and developmental plasticity. Finally, in the last chapter, with the construction phase nearing completion, we examine the emergence of behavior. This new edition reflects the complete modernization of the field that has been achieved through the intensive application of molecular, genetic, and cell biological approaches. It is richly illustrated with color photographs and original drawings. Combined with the clear and concise writing, the illustrations make this a book that is well suited to students approaching this intriguing field for the first time.
- Thorough survey of the field of neural development
- Concise but complete, suitable for a one semester course on upper level undergraduate or graduate level
- Focus on fundamental principles of organogenesis in the nervous system
- Integrates information from a variety of model systems, relating them to human nervous system development, including disorders of development
- Systematically develops knowledge from the description of key experiments and results
- Organized ontologically
- Carefully edited to be presented in one voice
- New edition thoroughly updated and revised to include major new findings
- All figures in full color, updated and revised
- Specific attention on revising the chapter on cognitive and behavioral development to provide a foundation and outlook towards those very fast moving areas
- Instructor website with figure bank and test questions
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2. Polarity and Segmentation
3. Birth and Migration
4. Determination and Differentiation
5. Axon Growth and Guidance
6. Target Selection
7. Naturally Occuring Neuron Death
8. Synapse Formation and Function
9. Refinement of Synaptic Connectivity
10. Behavioral and Cognitive Development
Dr. Sanes is Professor in the Center for Neural Science and Department of Biology at New York University. Named a Fellow of the American Association for the Advancement of Science (AAAS) in 2010 for his research in auditory central nervous system development, his research has been supported by the National Institute on Deafness and Other Communication Disorders and the National Science Foundation. His lab studies synaptic plasticity and central auditory processing, and the phenomenon of hearing loss during development.
Reh, Thomas A.
Dr. Reh is Professor of Biological Structure and Director of the Neurobiology and Behavior Program at the University of Washington. He is currently a member of the Scientific Advisory Board of the Foundation Fighting Blindness, and of a start-up biotechnology company, Acucela. He has received several awards for his work, including the AHFMR and Sloan Scholar awards and has published over 100 journal articles, reviews and books. Funded by numerous N.I.H. and private foundation grants, his lab is focused on the development and repair of the retina, with an overall goal of understanding the cellular and molecular biology of regeneration in the eye.
Harris, William A.
Dr. Harris is co-chair of Cambridge Neuroscience and Director of Studies in Neuroscience. He is also Head of the Department of Physiology, Development, and Neuroscience, and is Professor of Anatomy. Elected a Fellow of the Royal Society of London in 2007, he was Professor of Biology at UCSD prior to accepting a position at Cambridge. His lab is working to elucidate the cellular and molecular events that are used to push or induce cells to transition from proliferating stem cells to differentiated neurons and glia, and how particular regions of the nervous system produce the right number of neurons and the right proportions of different neuron subtypes.