This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, Dynamics of Bone and Cartilage Metabolism, Second Edition, is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases.
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PART I Components of the Organic Extracellular Matrix of Bone and Cartilage 1. Structure, Biosynthesis and Gene Regulation of Collagens in Cartilage and Bone 2. Fibrillogenesis and Maturation of Collagens 3. Vitamin K Dependent Proteins of Bone and Cartilage 4. Non-collagenous Proteins; Glycoproteins and Related Proteins 5. Proteoglycans and Glycosaminoglycans 6. Growth Factors 7. Prostaglandins and Proinflammatory Cytokines 8. Integrins and Other Adhesion Molecules 9. Alkaline Phosphatases 10. Acid Phosphatases 11. Matrix Proteinases
PART II Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage 12. Mineralization, Structure and Function of Bone 13. Bone Structure and Strength 14. The Cells of Bone 15. Signalling in bone 16. Parathyroid Hormone: Structure, Function and Dynamic Actions 17. Interaction of Parathyroid Hormone-Related Peptide with the Skeleton 18. The Vitamin D Hormone and Its Nuclear Receptor: Mechanisms Involved in Bone Biology 19. Sex Steroid Effects on Bone Metabolism 20. Physiology of Calcium and Phosphate Homeostasis 21. The Central Control of Bone Remodelling 22. New Concepts in Bone Remodeling 23. Products of Bone Collagen Metabolism 24. Supramolecular Structure of Cartilage Matrix 25. Products of Cartilage Metabolism 26. Fluid Dynamics of the Joint Space and Trafficking of Matrix Products 27. Transgenic Models of Bone Disease
PART III Markers of Bone and Cartilage Metabolism 28. The Role of Genetic Variation in Osteoporosis 29. Measurement of Calcium, Phosphate and Magnesium 30. Measurement of Parathyroid Hormone 31. New Horizons for Assessment of Vitamin D Status in Man 32. Measurement of Biochemical Markers of Bone Formation 33. Measurement of Biochemical Markers of Bone Resorption 34. Variability in the measurement of biochemical markers of bone turnover 35. Validation of Biochemical Markers of Bone Turnover 36. Genetic Markers of Joint Disease 37. Body Fluid Markers of Cartilage Metabolism 38. Laboratory Assessment of Postmenopausal Osteoporosis 39. Monitoring of Anabolic Treatment 40. Monitoring of anti-resorptive treatment 41. Age-Related Osteoporosis and Skeletal Markers of Bone Turnover 42. Osteoporosis in Men 43. Steroid-Induced Osteoporosis 44. Transplantation Osteoporosis: Biochemical Correlates of Pathogenesis and Treatment 45. Secondary Osteoporosis 46. Osteomalacia and Rickets 47. Assessment of Bone and Joint Diseases: Renal Osteodystrophy 48. Primary Hyperparathyroidism 49. Paget's Disease of Bone 50. Metastatic Bone Disease 51. Rare Bone Diseases 52. Osteogenesis Imperfecta 53. Rheumatoid Arthritis and Other Inflammatory Joint Pathologies 54. Osteoarthritis and Degenerative Spine Pathologies
Markus J Seibel, MD PhD FRACP FAHMS, is Professor of Endocrinology at Sydney Uni¬versity. He is the Inaugural Director of the Bone Research Program at the ANZAC Research Institute, and heads the Department of Endocrinology & Meta¬bolism at Concord Hospital, Sydney.
His research in musculoskeletal biology covers topics such as glucocorticoid signalling in bone and its effects on bone and systemic fuel metabolism and ageing; the biology of bone metastases; and the clinical efficacy of secondary fracture prevention programs.
Prof Seibel has published over 400 scientific papers and is the editor of 8 books. In 2017, he has been elected to the Australian Academy of Health and Medical Sciences. Prof Seibel is a Past President of the Australia and New Zealand Bone & Mineral Society (ANZBMS), a Member of the Board of Directors, International Federation of Musculoskeletal Research Societies (IFMRS), and the Chair of the Australian National Alliance for Secondary Fracture Prevention.
Simon P. Robins Rowett Research Institute, Aberdeen, U.K..
John P. Bilezikian Columbia University, New York, New York, U.S.A..
John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians & Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700.