Fertilization

  • ID: 1761511
  • Book
  • 427 Pages
  • Elsevier Science and Technology
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Fertilization provides in-depth reviews of individual research topics, while emphasizing key concepts and the significance of findings within other fields. The author identifies essential questions to be answered by future research. Fertilization broadly covers the many molecular and cellular events of animal fertilization and includes a section on unique problems and potential applications of fertilization research.
  • Provides in-depth reviews of individual research topics
  • Emphasizes key concepts and significance of findings to other fields
  • Broadly covers the many molecular and cellular events of animal fertilization
  • Includes a section on unique problems and potential applications of fertilization research
  • Identifies essential questions to be answered by future research
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Contributors

Preface


Acknowledgments


Section I Fertilization Events


1 Gamete Transport


I. Introduction


II. Sperm Transport


III. Oocyte Transport


IV. A Model for Gamete Transport


References


2 Sperm Motility ActIVation and Chemoattraction


I. Introduction


II. Assays


III. Motility Acquisition


IV. Motility ActIVation


V. Motility Modulation in the Female ReproductIVe Tract


VI. Egg-associated Motility Stimulation


VII. Chemoattraction


VIII. Concluding Remarks


References


3 Capacitation


I. Introduction


II. initiation, Propagation, and Termination of Capacitation


III. Molecular Mechanism of Capacitation


IV. Physiological Mechanism and Role of Capacitation


V Conclusions


References


4 Function of the Egg's Extracellular Matrix


I. Introduction


II. The Cumulus Oophorus


III. The Zona Pellucida


IV. Future Directions


References


5 Sperm Adhesion to the Extracellular Matrix of the Egg


I. Introduction


II. Basic Biology of Sperm-Eem Adhesion


III. Identification of Eem Adhesion Molecules


IV. Future Prospects and Directions


References


6 Signal Transduction Mechanisms Regulating Sperm Acrosomal Exocytosis


I. Introduction


II. Biogenesis and Morphology of the Acrosome


III. Biological Significance of Acrosomal Exocytosis


IV. Physiological Site of Acrosomal Exocytosis


V. The Zona Pellucida and Progesterone as Physiological Inducers of Acrosomal Exocytosis


VI. Sperm-associated Receptor/Binding Proteins for the Zona Pellucida and Progesterone


VII. Signal Transduction Mechanisms Mediating the Effects of the Zona Pellucida and Progesterone


References


7 Regulation of Sperm Lon Currents


I. Importance of Ion Channels


II. Sperm Ion Transport and EnVIronmental Sensing


III. Modulation of Sperm Ion Transport by Diffusible Egg Components


IV. Modulation of Sperm Ion Transport During the Acrosome Reaction


V. Spermatogenic Cells, A New Tool To Study Sperm Ion Channels


VI. Concluding Remarks


References


8 Function of the Sperm Acrosome


I. Introduction


II. The Prevailing View: the Acrosome Reaction Model


III. An AlternatIVe Paradigm: the Acrosomal Exocytosis Model


IV. Other Considerations of Acrosomal Proteins


V. Future Directions


VI. Summary


References


9 Gamete Fusion in Mammals


I. Introduction


II. Specificity of Gamete Fusion


III. A Hypothetical Pathway Leading to Sperm-Egg Fusion


IV. Sperm and Egg Surface Proteins Involved in Gamete Binding and Fusion


V. Hypothetical Steps After Binding and Before Fusion


VI. Sperm Tail Stiffening


VII. Fusion in Other Systems


VIII. Prospectus


References


10 Membrane Events of Egg Activation


I. Introduction


II. Ca2+ Waves and Oscillations At Fertilization


III. Electrical Events and Fertilization


IV. The Latent Period of Fertilization 327


V. Signaling Molecules and Mechanisms Leading To Ca2+ Release


VI. Sperm as a Ca2+ Conduit


VII. Sperm Contact as the Signal


VIII. The Sperm Content Hypothesis


IX. Conclusions


References


Section II Unique Problems and Applications


11 Molecular Genetics of Fertilization


I. Introduction


II. Gametes Have Unusual Characteristics


III. Genetic Model Systems


References


12 Gamete Immunobiology


I. Introduction


II. Fetal and Neonatal Germ Cells


III. The Developing Immune System


IV. Immune Response To Gametes in the Fetal, Neonatal, and Prepubertal Stages


V. Immune Response To Gametes in the Adult


VI. Immune Response To Male Gametes in the Adult Female


VII. Concluding Remarks


References


13 Fertilization Biophysics


I. Introduction


II. Sperm as Force-Generating Machines


III. Tethering Sperm


IV. Sperm Capture By Eggs


V. Sperm Penetration of Egg Coats


VI. The Transition From Sperm Adhesion To Penetration of the Zona Pellucida


VII. Summary


References


14 Applications of Fertility Regulation for the Management of Wild and Domestic Species


I. Introduction


II. Case Studies On Wildlife Management


III. Fertility Control: Targets and Immunological Intervention


IV. Reproductive Tract Immune Responses


V. Bait DelIVery of An ImmunocontraceptIVe Vaccine


VI. Concluding Remarks


References


Index


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Hardy, Daniel M.
Garbers, D. L.
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