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Folic Acid and Folates, Vol 79. Vitamins and Hormones

  • ID: 1761708
  • Book
  • November 2008
  • 480 Pages
  • Elsevier Science and Technology
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First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms.

*Includes color illustrations
*Available on [external URL]
*Longest running series published by Academic Press
*Contributions by leading international authorities

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1. Folate-Mediated One-Carbon Metabolism
Jennifer T. Fox and Patrick J. Stover

2. Mathematical Models of Folate-Mediated One-Carbon Metabolism
H. Frederik Nijhout, Michael C. Reed and C.M. Ulrich

3. Folate Deprivation, the Methionine Cycle and Alzheimer¡ - s Disease
Flaubert Tchantchou and Thomas B. Shea

4. Benefits and Risks of Folic Acid Supplementation
Young-In Kim

5. Molecular Mechanisms of Adaptation to Folate Deficiency
Ilan Ifergan and Yehuda G. Assaraf

6. Structure and Function of the Reduced Folate Carrier: A Paradigm of a Major Facilitator Superfamily Mammalian Nutrient Transporter
Larry H. Matherly and Zhanjun Hou

7. Renal Conservation of Folates: Role of Folate Transport Proteins
Vijaya L. Damaraju, Carol E. Cass and Michael B. Sawyer

8. Exploitation of the Folate Receptor in the Management of Cancer and Inflammatory Disease
Christopher P. Leamon and Ann L. Jackman

9. Folate Receptor Expression in Pituitary Adenomas: Cellular and Molecular Analysis
Chheng-Orn Evans, Congjun Yao, David Leborde and Nelson M. Oyesiku

10. Regulation of Human Dihydrofolate Reductase Activity and Expression
Emine Ercikan Abali, Nancy E. Skacel, Hilal Celikkaya, Yi-Ching Hsieh

11. Catalysis of Methyl Group Transfers Involving Tetrahydrofolate and B12
Stephen W. Ragsdale

12. Methyltetrahydrofolate in Folate-Binding Protein Glycine N-Methyltransferase
Zigmund Luka

13. Mechanism-Based Inhibitors of Folylpoly-f×-glutamate Synthetase and f×-Glutamyl Hydrolase: Control of Folylpoly-f×-glutamate Homeostasis as a Drug Target
James K. Coward and John J. McGuire

14. Methylenetetrahydrofolate Reductase, Common Polymorphisms and Relation to Disease
Philip Thomas and Michael Fenech

15. Mitochondrial Methylenetetrahydrofolate Dehydrogenase, Methenyltetrahydrofolate Cyclohydrolase and Formyltetrahydrofolate Synthetases
Karen E. Christensen and Robert E. MacKenzie

16. The Structure and Mechanism of 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase
Jeremy P. Derrick
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Litwack, Gerald.
Trained in biochemistry at the University of Wisconsin, Madison, Dr. Litwack worked on enzymology and the effects of hormones on enzyme systems. Then he was a Postdoctoral Fellow of the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. Dr. Litwack's first position was as Assistant Professor of Biochemistry at Rutgers University in 1954. Six years later, he joined the University of Pennsylvania as associate professor and four years later went to the Fels Institute for Cancer Research and Molecular Biology, as full professor, eventually becoming Deputy Director of the Institute. In 1991, he accepted the Chair of Pharmacology at Thomas Jefferson University where he is also Deputy Director of the Jefferson Cancer Institute and Associate Director for Basic Science in the Jefferson Cancer Center. Dr. Litwack's work has been in the area of mechanisms of steroid receptor action involving especially the glucocorticoid and mineralocorticoid receptors, immunophi.

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