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Genetic Mapping of Disease Genes

  • ID: 1762053
  • Book
  • 288 Pages
  • Elsevier Science and Technology
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A state-of-the-art reference, Genetic Mapping of Disease Genes presents a detailed account of the new methodical approaches to gene mapping. It provides completely up-to-date information and comprehensive coverage of research in this field, and includes contributions from the leading experts. The book gives a broad overview of the genetic mapping involved in inherited diseases and discusses the shortcomings of established mapping procedures.
The book will be essential reading for all researchers and postgraduate research students in molecular genetics, clinical genetics, and molecular biology, but also those involved in ophthalmology, public health, medical statistics, and mathematics.

The volume covers:

  • Introduction and History
  • Linkage in Dominant Recessive and Oligogenic Disease
  • Model Free (Non-Parametric) Methods
  • Tools (for Gene Mapping)
  • Applications

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Introduction and History:J.H. Edwards, Introduction.A.W.F. Edwards, The Early History of the Statistical Estimation of Linkage.
Linkage in Dominant, Recessive, and Polygenic Disease:N.E. Morton and P. Lio, Oligogenic Linkage and Map Integration.J. Ott, Genetic Mapping in Complex Disorders.J.H. Edwards, Recessive Disease and Allelic Association.T. Grimm, Mutation-Selection-Equilibria, Genetic Models, and Linkage Analysis.D. Stephens and C.A.B. Smith, Simple Likelihood and Probability Calculations for Linkage Analysis.
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Pawlowtzki, Ivar-Harry
Edwards, J. G.
Thompson, Elizabeth A.
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