The present volume is the first in the advances in oncobiology series. It is meant to be useful not only to clinical and non-clinical oncologists but also to graduate students and medical students. The individual chapters are presented as self-contained summaries of current knowledge rather than as reviews. The last chapter deals with the subject of chemotherapy.
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Preface (G. Heppner) Pathobiology of Neoplasia (D.W. Visscher and G.H. Heppner) Cancer Induction by Ionizing Radiation (K.L. Mossman) Environmental Causes of Cancer (J.S. Malpas) Progestin Regulation of Cellular Proliferation (E.A. Musgrove and R.L. Sutherland) Tumor Angiogenesis and its Control by Tumor Suppressor Genes (P.J. Polverini) The Role of Gap Junctional Intercellular Communication in Neoplasia (R.J. Ruch) Cell Adhesion and Metastasis: Molecular Mechanisms (C.W. Evans) RAS: Processor of Vital Signals (C.M. Weyman and D.W. Stacey) Human Cytokines (B.G. Darnay and B.B. Aggarwal) Immunity to Cancer: Cytotoxic Lymphocytes, Interleukin-2, and the Tumor Necrosis Factor Superfamily (M.J. Robertson and J. Ritz) Quantitative Analysis of Nuclear Size for Prognosis-Related Malignancy Grading (F.B. Sørensen) Prostate Cancer (M. Gleave, M. Bandyk, and L. Chung) The Biology of Human Melanoma (S.Q. Lynch, P.M. Doskoch, S. Vijayasaradhi, and A.N. Houghton) Aspects of the Treatment of B Cell Malignancies (A.Z.S. Rohatiner, J.S. Malpas, and R.K. Ganjoo) Principles of Cancer Chemotherapy (J.S. Malpas and A. Rohatiner)