Supramolecular Reactivity and Transport: Bioorganic Systems

  • ID: 1763962
  • Book
  • Elsevier Science and Technology
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This volume containing 15 chapters is practically classified into four parts. Part 1 deals with rapidly growing areas in bioorganic chemistry, covering antibody catalysis, structural aspects of DNA and DNA binding agents and protein mimetics. Part 2 describes receptor functions in relation to biochemical phenomena. Part 3 involves biomimetic reactions covering electron and energy transfer in supramolecular model systems, metalloporphyrin catalysis, zinc enzyme models and artificial enzymes with Vitamin B6 and B12 activity. Some aspects of enzyme chemistry are described in Part 4, covering kinetic, thermodynamic and supramolecular aspects of enzyme catalysis and site-directed mutagenesis of proteins.
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Historical perspectives and general introduction (C. Brückner, L.Y. Xie, D. Dolphin). Catalytic antibodies: chemical and biological approaches (K.D. Janda, C.G. Shevlin, C.-H.L. Lo). DNA binding agents (D.S. Johnson, D.L. Boger). Nucleic acids: supramolecular structures and rational design of sequence-specific ligands (C. Giovannangeli, J.-S. Sun, C. Hélène). Protein mimetics (T. Sasaki, M. Lieberman). Template- assembled synthetic proteins (M. Mutter, G. Tuchscherer). Receptors based on cholic acid (A.P. Davis, R.P. Bonar-Law, J.K.M. Sanders). Supramolecular neocarzinostatin complex (T. Tanaka, M. Hirama, S. Imajo, M. Ishiguro). Electron-and-energy transfer reactions in noncovalently linked supramolecular model systems (J.L. Sessler, B. Wang, S.L. Springs, C.T. Brown). Biomimetic reactions catalyzed by metalloporphyrins (H. Ogoshi, T. Mizutani). Models for zinc-containing enzymes (A.M. Ridder, R.M. Kellogg). Artificial enzymes with vitamin B6 and B12 activity (Y. Murakami, J. Kikuchi,Y. Hisaeda, T. Ohno). Supramolecular aspects of enzyme enantioselectivity (J.A. Jongejan, J.A. Duine). Supramolecular aspects of enzymes (D.H. Kim). Towards design of artificial enzymes and receptors through site-directed mutagenesis of
proteins (H. Kondo).

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Murakami, Y.
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