Vitamin K, Vol 78. Vitamins and Hormones

  • ID: 1765619
  • Book
  • 300 Pages
  • Elsevier Science and Technology
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Vitamin K, one of the group of fat-soluble vitamins (A, D, E and K), has come into prominence lately because its activity as a blood coagulation factor impinges on the widespread occurrence of deep vein thrombosis in the human population especially in the older age group. This volume focuses, not only on the problem of blood coagulation and hypercoagulability, but upon the individual status of vitamin K in the human.

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists.

*Focuses on the problem of blood coagulation and hypercoagulability as well as bone metabolism and vascular biology
*In the category of basic science, contributions cover: VKOR1, the quinone reductases including structure, function and mechanism, vitamin K-dependent carboxylation, the actions of Gas6, vitamin K2-mediated apoptosis and other topics
*In the category of disease-related subjects, contributions cover warfarin therapy, diabetic nephropathy, bone health, including osteoporosis and tumor cell suppression, as well as other topics
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CRYSTAL STRUCTURE OF HUMAN QUINONE REDUCTASE
Gas6 GENE IN EARLY DIABETES
VITAMIN K-DEPENDENT ?×-CARBOXYLATION
VITAMIN K-DEPENDENT CARBOXYLATION
DETERMINANTS OF VITAMIN K IN HUMANS
VITAMIN K AND BONE CONDITION IN HUMAN ADULTS
VITAMIN K DEPENDENT Gas6 ACTION
CONGENITAL BLEEDING DISORDERS OF THE VITAMIN K DEPENDENT CLOTTING FACTORS
DIAGNOSIS OF OSTEOPOROSIS
QUINONE OXIDOREDUCTASES AND VITAMIN K METABOLISM
DEEP VEIN THROMBOSIS AND VITAMIN K
HEPATOCELLULAR CARCINOMA AND VITAMIN K
VITAMIN K AND MITOCHONDRIAL TRANSMEMBRANE POTENTIAL
NEW UNDERSTANDING OF THE VITAMIN K CYCLE AND ITS DOWNSTREAM PATHWAYS
VKORC1 AND THE VITAMIN K CYCLE
STRUCTURE AND FUNCTION OF VITAMIN K EPOXIDE REDUCTASE
WARFARIN THERAPY AND VITAMIN K
VKORC1 AND HUMAN CLOTTING FACTORS
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Litwack, Gerald.
Trained in biochemistry at the University of Wisconsin, Madison, Dr. Litwack worked on enzymology and the effects of hormones on enzyme systems. Then he was a Postdoctoral Fellow of the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. Dr. Litwack's first position was as Assistant Professor of Biochemistry at Rutgers University in 1954. Six years later, he joined the University of Pennsylvania as associate professor and four years later went to the Fels Institute for Cancer Research and Molecular Biology, as full professor, eventually becoming Deputy Director of the Institute. In 1991, he accepted the Chair of Pharmacology at Thomas Jefferson University where he is also Deputy Director of the Jefferson Cancer Institute and Associate Director for Basic Science in the Jefferson Cancer Center. Dr. Litwack's work has been in the area of mechanisms of steroid receptor action involving especially the glucocorticoid and mineralocorticoid receptors, immunophi.

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