This single volume, written by the most prominent authors in the field, brings together for the first time information about the most widely studied IEG/ITF in a whole variety of phenomena of neuronal activation. It starts with a critical appraisal of the technologies employed for the studies on gene, protein, and transcription factor activity in the nervous system. Several chapters present exhaustive examples of expression patterns of the ITF in "vocal" avian brain, mammalian brain sensory regions, areas involved in regulation of circadian rhythms, and the spinal cord. The next parts cover functional and regular aspects of individual IEG/ITF expression: c-fos in learning and memory, c-jun and others in neuropathology and neuronal stress responses, Elk-1, egr family, and CREB in neuronal plasticity and learning.
This volume will be useful as a major reference on this topic. Furthermore, it attempts to unravel the seemingly overwhelming complexity of the phenomena of gene expression in the central nervous system.
1. Methods used in inducible transcription factor studies focus on MRNA (B. Ziokowska, R. Przewocki).
2. Neuroanatomical and functional mapping using activation of transcription factors (M. Dragunow, D. Bilkey).
3. Studies of the DNA binding activity of transcription factors in mapping brain function (B. Kaminska).
4. Immediate early gene (IEG) expression mapping of vocal communication areas in the avian brain (C.V. Mello).
5. Molecular activity maps of sensory function (A.Chaudhuri, S. Zangenehpour).
6. Immediate-early gene expression in the analysis of circadian rhythms and sleep (B. Rusak, M.E. Guido, K. Semba).
7. The expression of C-FOS in the spinal cord. Mapping of nociceptive pathways (H. Bester, S.P. Hunt).
8. C-FOS in learning: beyond the mapping of neuronal activity (L. Kaczmarek).
9. Mapping neuropathology with inducible and constitutive transcription factors (A. Pearson, M. Dragunow).
10. C-JUN, JNK and P38: visualization of neuronal stress responses (T. Herdegen, S. Brecht).
11. ELK-1: an important regulator of immediate early gene expression in the brain (P. Vanhoutte, J. Caboche).
12. The EGR transcription factors and their utility in mapping brain functioning (J. Leah, P.A. Wilce).
13. Creb plasticity and memory (S.A. Josselyn, S. Kida, P. de Ortiz, A.J. Silva).