- Contains practical descriptions of how to analyze kinetic data- Provides examples of how to develop and use models- Describes several software packages including SAAM/CONSAM- Includes software with working models
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What is Modeling?
The Steps in Building a Model.
The Difference Between Building a Model and Using a Model.
Why Model Biological Systems?
Review of Software.
Concepts and Tools of Modeling:
Building Models in Sections.
Techniques and Tools to Facilitate Model Development.
Strategies for Modeling Biological Systems:
Experimental Design and Data Collection.
Starting Modeling and Developing a Model.
Rejecting Hypotheses and Accepting a Model.
Multiple Studies Analysis.
Information in the Model.
Errors in Compartmental Modeling.
Testing Robustness: Sensitivity, Identifiability, and Stability.
Evaluating and Using Published Models:
Why Use a Published Model?
Reviewing and Summarizing Published Models.
The Model Translation Process.
Verification and Validation.
Using the Model.
A Library of Models.
Meryl Wastney is an Associate Professor in the Department of Pediatrics and the Department of Biomathematics and Biostatistics at the Georgetown University Medical Center in Washington D.C. She received her Ph.D. in biochemistry from Lincoln College at the University of Canterbury in New Zealand. She was a Fogarty Fellow in the Laboratory of Mathematical Biology, NCI, NIH, Bethesda, Maryland for three years and joined the Department of Pediatrics at Georgetown University in 1983. She is the author of 30 articles and has presented over 40 invited lectures and workshops on modeling biological systems.
Patterson, Blossom H.
Linares, Oscar A.
Greif, Peter C.
Boston, Raymond C.