How do cells regulate the activity of these channels? How might we restore their normal function? In Ion Channel Regulation, many of the experts who pioneered these discoveries provide detailed summaries of our current understanding of the molecular mechanisms that control ion channel activity.
- Reviews brain functioning at the fundamental, molecular level
- Describes key systems that control signaling between and within cells
- Explains how channels are used to stimulate growth and changes to activity of the nucleus and genome
Protein Phosphorylation.S. Rossie, Regulation of Voltage-Sensitive Sodium and Calcium Channels by Phosphorylation.S.L. Swope, S.J. Moss, L.A. Raymond, and R.L. Huganir, Regulation of Ligand Gated Ion Channels by Protein Phosphorylation.D.C. Gadsby and A.C. Nairn, Regulations of CFTR Cl- Ion Channels by Phosphorylation and Dephosphorylation.
Second Messengers:M. Biel, X. Zong, and F. Hofmann, Cyclic Nucleotide-Gated Channels.R.E. White, Cyclic GMP and Ion Channel Regulation.
Closely Associated Proteins:S.R. Ikeda and K. Dunlap, Voltage-Dependent Modulation of N-Type Calcium Channels: Role of G Proteins Subunits.
Novel Pathways.J.-L. Sui, K. Chan, M.-N. Langan, M. Vivaudou, and D.E. Logothetis, G Protein-Gated Potassium Channels.A.C. Dolphin, L Type Calcium Channel Modulation by G Proteins.
Novel Pathways:S.G. Rane, Ion Channels as Physiological Effectors for Growth Factor Receptor and Ras/ERK Signaling Pathways.R.S. Lewis, Store-Operated Calcium Channels.
Nairn, Angus C.
Angus C. Nairn is currently Associate Professor at The Rockefeller University. He has published a large number of papers concerned with the structure and regulation of protein kinases and phosphatases involved in signal transduction, particularly with respect to signalling by calcium.
Armstrong, David L.