The discovery of their glycosyl-phosphatidylinositol (GPI) anchor has led to the discovery, in polar epithelial cells, of a specific targeting mechanism for GPI-anchored surface glycoproteins. Over one hundred such proteins have been detected in metazoans since then.
Many of these basic aspects are dealt with in this book using quite different methodical approaches. Of course, there are many more aspects previously known from metazoan systems and such aspects then had to be verified also for Protozoa systems and such aspects then had to be verified also for protozoa. In this context, it is fascinating to see how basic cellular functions are maintained - with variations of the basic theme - throughout evolution.
However, sometimes cell biologists dedicated to work with protozoa have to live with a regrettable phenomenon. Colleagues working with "higher" eukaryotic cells are frequently unaware of the fact that the primary input may have come from work with protozoa. Some phenomena may even be rediscovered inadvertently. In this sense, this book should address not only colleagues working with protozoa but also many of our fellow cell biologists working with metazoan cells.