Computer-based design and modeling, computational approaches, and instrumental methods for elucidating molecular mechanisms of protein folding and ligand-acceptor interactions are included in Volumes 202 and 203, as are genetic and chemical methods for the production of functional molecules including antibodies and antigens, enzymes, receptors, nucleic acids and polysaccharides, and drugs.
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Design and Modeling:R.A. Lewis, Clefts and Binding Sites in Protein Receptors.N. Summers and M. Karplus, Modeling of Side Chains, Loops, and Insertions.L.H. Holley and M. Karplus, Neural Networks.V.E. Reyes, R.A. Lew, S. Lu, and R.E. Humphreys, Prediction of ~ga Helices and T-Cell-Presented Sequences in Proteins with Algorithms Based on Strip-of-Helix Hydrophobicity Index.J. Greer, Comparative Modeling of Homologous Proteins.B.I. Cohen, S.R. Presnell, and F.E. Cohen, Pattern-Based Approaches to Protein Structure Prediction.J. de Vlieg and W.F. van Gunsteren, Combined Procedures of Distance Geometry and Molecular Dynamics ~for Determining Protein Structure from NMR Data.J. Ellman, S. Anthony-Cahill, C.J. Noren, and P.G. Schultz, Biosynthetic Method for Introducing Unnatural Amino Acids Site Specifically into Proteins.M. Matsumura and B.W. Matthews, Stabilization of Functional Proteins by Introduction of Multiple Disulfide Bonds.C.A. Hutchison III, R. Swanstrom, and D. Loeb, Complete Mutagenesis of Protein Coding Domains.J.A. Wells, Systemic Mutational Analysis of Protein-Protein Interfaces.P.E. Smith, F. Al-Obeidi, and B.M. Pettitt, Design of Conformationally Constrained Peptides.W.M. Bryan, Design of Minimum Active Fragments of Biologically Active Peptides.A.D. MacKerell, Jr. , Molecular Modeling and Dynamics of Biologically Active Peptides: Application~to Neuropeptide Y.
Enzymes:M.E. Davis, J.D. Madura, J. Sines, B.A. Luty, S.A. Allison and J.A. McCammon, Diffusion-Controlled Enzymatic Reactions.T.P. Straatsma and J.A. McCammon, Theoretical Calculations of Relative Affinities of Binding.C. Hansch and T.E. Klein, QSAR and Molecular Graphics in Evaluation of Enzyme-Ligand Interactions.A.J. Leo, Hydrophobic Parameter: Measurement and Calculation.C.-H. Wong, G.-J. Shen, R.L. Pederson, Y.F. Wang, and W.J. Hennen, Enzymatic Catalysis in Organic Synthesis.G. Alvaro and A.J. Russell, Modification of Enzyme Catalysis by Engineering Surface Charge.R. Bone and D.A. Agard, Mutational Remodeling of Enzyme Specificity.L. Hedstrom, L. Grath, C.B. Stewart, W.J. Rutter, and M.A. ~Phillips, Modulation of Enzyme Specificity by Site-Directed Mutagenesis.M.E. Wales and J.R. Wild, Analysis of Structure-Function Relationships by Formation of Chimeric Enzymes Produced by Gene Fusion.L.C. Kuo, Generation of Allosteric Enzymes from Nonallosteric Forms.I.T. Weber, Modeling of Structure of HIV-1 Protease with Substrate Based on the Crystal Structure of RSV Protease.R.L.P. Lindberg and M. Negishi, Modulation of Specificity and Activity in Mammalian Cytochrome P450.
Cross-Index to Prior Volumes:J.T. Langone, Related Chapters in Previous Methods in Enzymology Volumes.
Each chapter includes references.