Multiple Sclerosis As A Neuronal Disease

  • ID: 1768497
  • Book
  • 496 Pages
  • Elsevier Science and Technology
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This book examines the role of neurons in multiple sclerosis (MS) and the changes that occur in neurons as a result of MS. It places MS in a new and important perspective that not only explains the basis for symptom production, remission, and progress in MS, but also promises to open up new therapeutic possibilities.

* Brings together the latest information from clinical, pathological, imaging, molecular, and pharmacological realms to explore the neurobiology of Multiple Sclerosis
* Places MS in a new and important perspective that promises to open up new therapeutic avenues
* Superbly illustrated and referenced

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Preface

Contributors


I Structure, Molecular Organization, and Function of Myelinated Axons


1. The Structure of Myelinated Axons in the CNS


2. Dialogues: Communication Between Axons and Myelinating Glia


3. Molecular Specializations at the Glia-Axon Interface


4. Potassium Channel Organization of Myelinated and Demyelinated Axons


5. The Roles of Potassium and Calcium Channels in Physiology and Pathophysiology of Axons


II Neuronal Concomitants of Demyelination


6. The Conduction Properties of Demyelinated and Remyelinated Axons


7. Altered Distributions and Functions of Multiple Sodium Channel Subtypes in Multiple Sclerosis and Its Models


8. Na+ Channel Reorganization in Demyelinated Axons


9. Ion Currents and Axonal Oscillators: A Possible Biophysical Basis for Positive Signs and Symptoms in Multiple Sclerosis


10. Clinical Pharmacology of Abnormal Potassium Channel Organization in Demyelinated Axons


III Multiple Sclerosis as a Neurodegenerative Disease


11. Pathology of Neurons in Multiple Sclerosis


12. Axonal Degeneration in Multiple Sclerosis: The Histopathological Evidence


13. Natural History of Multiple Sclerosis: When Do Axons Degenerate?


IV Measurement of Neuronal Changes in the Clinical Domain


14. Brain Atrophy as a Measure of Neurodegeneration and Neuroprotection


15. MRI-Clinical Correlations in Multiple Sclerosis: Implications for Our Understanding of Neuronal Changes


16. Electrophysiological Correlates of Relapse, Remission, Persistent Sensorimotor Deficit, and Long-Term Recovery Processes in Multiple Sclerosis


V Cellular and Molecular Mechanisms of Axonal Degeneration in Multiple Sclerosis


17. Inflammation and Axon Degeneration


18. Nitric Oxide and Axonal Pathophysiology


19. Molecular Mechanisms of Calcium Influx in Axonal Degeneration


20. Axonal Damage and Neuron Death in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: The Role of Calpain


21. Mutations of Myelination-Associated Genes That Affect Axonal Integrity


VI Other Aspects of Neuronal Injury in Multiple Sclerosis


22. Neuronal Blocking Factors in Demyelinating Diseases


23. Evidence for Neuronal Apoptosis in Demyelinating CNS Diseases


VII Lessons from the Peripheral Nervous System


24. Mechanisms Underlying Wallerian Degeneration


25. AMAN: What It Teaches Us about Mechanisms Underlying Axonal Injury


VIII Prognosis, Reparative Mechanisms, and Therapeutic Approaches


26. Axonal Degeneration as a Predictor of Outcome in Neurological Disorders


27. Remyelination as Neuroprotection


28. Transplantation of Peripheral-Myelin-Forming Cells to Repair Demyelinated Axons


29. Blocking the Axonal Injury Cascade: Neuroprotection in Multiple Sclerosis and Its Models


30. Functional Brain Reorganization and Recovery after Injury to White Matter


Index
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Waxman, Stephen
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