Mathematical and computational biology is playing an increasingly important role in the biological sciences. This science brings forward unique challenges, many of which are, at the moment, beyond the theoretical techniques available. Developmental biology, due to its complexity, has lagged somewhat behind its sister disciplines (such as molecular biology and population biology) in making use of quantitative modeling to further biological understanding. This volume comprises work that is among the best developmental modeling available and we feel it will do much to remedy this situation.
This book is aimed at all those with an interest in the interdisciplinary field of computer and mathematical modeling of multi-cellular and developmental systems. It is also a goal of the Editors to attract more developmental biologists to consider integrating modeling components into their research. Most importantly, this book is intended to serve as a portal into this research area for younger scientists - especially graduate students and post-docs, from both biological and quantitative backgrounds.
* Articles written by leading exponents in the field
* Provides techniques to address multiscale modeling
* Coverage includes a wide spectrum of modeling approaches
* Includes descriptions of the most recent advances in the field
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Models of biological pattern formation: from elementary steps to the organization of embryonic axes
Robustness of embryonic spatial patterning in Drosophila melanogaster
Integrating morphogenesis with underlying mechanics and cell biology
The mechanisms underlying primitive streak formation in the chick embryo
Grid-free models of multicellular systems, with an application to large-scale vortices accompanying primitive streak formation
Mathematical models for somite formation
Coordinated Action of N-CAM, N-cadherin, EphA4 and ephrinB2 Translates Genetic Prepatterns into Structure during Somitogenesis in Chick
Branched organs: Mechanics of morphogenesis by multiple mechanisms
Multicellular sprouting during vasculogenesis
Modelling lung branching morphogenesis
Multiscale Models for Vertebrate Limb Development
Tooth morphogenesis in vivo, in vitro and in silico
Cell mechanics with a 3D kinetic and dynamic weighted Delaunay-triangulation
Cellular automata as microscopic models of cell migration in heterogeneous environments
Multiscale modeling of biological pattern formation
Relating Biophysical Properties Across Scales
Complex Multicellular Systems and Immune Competition: New Paradigms Looking for a