An accompanying volume (Volume 6) in this series presents strategies of cellular invasion from the viewpoint of the microbe.
This filed of study is growing rapidly after a somewhat slow start over recent decades. This collection of invited chapters attempts to reflect current research, and brings together cell biologists, microbiologists and immunologists with disparate interests. However, there is a certain unity, even repetition of key themes, hopefully like a symphony rather than a boring catalogue. It will be evident that editorial bias favors intracellular paratism and medically important organisms. The neutrophil is far more than a supporting player to the macrophage, and some attempt is made to remind the reader of some of its unique skills. To retain a manageable size, the emphasis is on relatively early events such as mutual recognition, cell entry, and response, rather than on longterm changes in gene expression by either host cell or pathogen. Viruses are excluded not because of lack of importance but because of somewhat different research approaches, although it is cytogenes, share common strategies in invasion and intercellular spread.
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D. Rotstein, and S. Grinstein). The Phagocyte Actin Cytoskeleton (H. Sun, K. Lin, M. Yamamoto, and H.L. Yin). Section V Responses. Nramp1: A Novel Macrophage Protein with a Key Function in Resistance to Intracellular Pathogens (S. Gruenheid, E. Skamene, and P. Gros). Uptake and Presentation of Phagocytosed Antigens by Dendritic Cells (M.L. Albert, S. Turley, W. Garrett, I. Mellman, K. Inaba, N. Bhardway, and R.M. Steinman). Processing and Presentation of Phagocytosed Antigens to the Immune System (J. Pieters). Antimicrobial Mechanisms of Macrophages (M.U. Shiloh and C.F. Nathan). Components and Organization of the Nadph Oxidase of Phagocytic Cells: Its Role in Microbial Killing and in the Molecular Pathology of Chronic Granulomatous Disease (A.W. Segal, f. wientjes, R.W. Stockley, and L.V. Dekker). Oxygen-Independent Antimicrobial Mechanisms of PMN (P. Elsbach). Index.