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Identification and characterization of functional hepatocyte nuclear factor 1 binding sites in UDP-Glucuronosytransferase genes; 3 Substrate Specificity of Human Hepatic UDP-Glucuronosyltransferaes; 4 UDP-glucuronosytransferase (UGT) 1A6: structural, functional and regulatory aspects; 5 The Role of Ah Receptor in Induction of Human UDP-glucuronosyltransferase 1A1; 6 Regulation of the human UGT1A1 gene by nuclear receptors CAR, PXR and GR; 7 Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases; 8 Structure of UDP-glucuronosyltransferases in membranes; 9 Human SULT1A genes: Cloning and activity assays of the SULT1A promoters; 10 Vitamin D Receptor Regulation of the Steroid/Bile Acid Sulfotransferase SULT2A1; 11 Screening and characterizing human NAT2 variant; 12 Inactivation of human arylamine N-acetyltransferase 1 by hydrogen peroxide and peroxinitrite; 13 SULT and NAT in Mutagenicity Testing: Technical Aspects; 14 A comparative molecular field analysis (CoMFA) based approach to prediction of sulfotransferase catalytic specificity; 15 Glucuronidase deconjugation in inflammation; 16 Three-dimensional structures of sulfatases; 17 Estrogen sulfatase; 18 Analysis for localization of steroid sulfatase in human tissues; 19 Metabolism of Phytoestrogen Conjugates; 20 Coenzyme Q and phenolic conjugate metabolism; 21 Synthesis of bile acid CoA thioesters in the amino acid conjugation of bile acids; 22 Bile acid CoA: amino acid N-acyltransferase in the amino acid conjugation of bile acids; 23 Multidrug resistance protein 1-mediated export of glutathione and glutathione disulphide from brain astrocytes; 24 The genetics of ATP-binding cassette transporters; 25 Functional analysis of detergent-solubilized and membrane-reconstituted ABC Transporters; 26 Yeast ABC transporters
Cellular cleaning pumps; 27 High-speed screening of human ABC transporter function and genetic polymorphisms: New strategies in pharmacogenomics; 28 Coordinate transcriptional regulation of transport and metabolism; 29 Uptake and efflux transporters for anionic conjugates in human Hepatocytes; 30 Biliary canalicular transport systems: short-term regulation; 31 Inborn errors of biliary canalicular transport systems; 32 Epoxide Hydrolases
Structure, function, mechanism and assay; 33 Pregnane X receptor-mediated transcription; 34 Animal models of xenobiotic receptors in drug metabolism and diseases; 35 Cancer and molecular biomarkers of Phase 2
Helmut Sies is an Honorary Member of the American Society for Biochemistry and Molecular Biology. He received an Honorary Ph.D. from the University of Buenos Aires, Argentina in 1996. Dr. Sies is a member of the Northrhine-Westphalian Academy of Sciences, Germany, and a Corresponding Member of both the Academy of Sciences of Heidelberg, Germany, and the Academy of Medicine, Buenos Aires, Argentina. He has received many awards and prizes, including the FEBS Anniversary Prize awarded by the Federation of European Biochemical Societies, 1978; the Distinguished Foreign Scholar award, MASUA, 1985; the Silver Medal, Karolinska Institute, Stockholm, 1986; the Ernst Jung Preis fur Medizin, 1988; the Claudius-Galenus-Preis, 1990; and the ISFE-Preis, 1994. Dr. Sies sereves on the editorial board and advisory committee for twelve journals, has edited numerous books, and has published more than 400 original articles and chapters. He received his M.D. at the University of Munich in 1967 and currently serves as Full Professor and Chairman of the Department of Physiological Chemistry at the University of D?sseldorf.