Several functional genomic approaches discussed in this volume address plant gene function on a large scale. Plants are combinatorial chemists par excellence, and understanding the principles that relate enzyme structure to function will open up unlimited possibilities for the rational design of new enzymes to generate novel biologically active natural products. Knowledge of the molecular genetics of plant natural product pathways will also facilitate the engineering of these pathways for plant improvement and human benefit. Phytochemistry truly has a great future in the genomics and post-genomics eras.
A genomics approach to plant one-carbon metabolism (S. Roje, A.D. Hanson).
Metabolomics: A developing and integral component in functional
genomic studies of medicago truncatula (L.W. Sumner et al.).
Metabolite profiling: from metabolic engineering to functional genomics (R.N. Trethewey).
Triterpenoid saponin biosynthesis in plants (A.E. Osbourn, K. Haralampidis).
A mutational approach to dissection of flavonoid biosynthesis in Arabidopsis (B. Winkel-Shirley).
Biopanning by activation tagging (Yiji Xia et al.).
Functional genomics of cytochromes P450 in plants (K.A. Feldmann et al.).
Functional genomics approaches to unravel essential oil biosynthesis (B. Markus Lange, R.E.B. Ketchum).
Sequence-based approaches to alkaloid biosynthesis gene identification (T.M. Kutchan).
An integrated approach to medicago functional genomics (G.D. May).
Structurally guided alteration of biosynthesis in plant type III
polyketide synthases (J.P. Noel et al.).
The role of cytochromes P450 in biosynthesis and evolution of
glucosinolates (B.A. Halkier et al.).