Principles of Behavioral Genetics

  • ID: 1769838
  • Book
  • 334 Pages
  • Elsevier Science and Technology
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Principles of Behavioral Genetics provides an introduction to the fascinating science that aims to understand how our genes determine what makes us tick. It presents a comprehensive overview of the relationship between genes, brain, and behavior.

Introductory chapters give clear explanations of basic processes of the nervous system and fundamental principles of genetics of complex traits without excessive statistical jargon. Individual chapters describe the genetics of social interactions, olfaction and taste, memory and learning, circadian behavior, locomotion, sleep, and addiction, as well as the evolution of behavior.

Whereas the focus is on genetics, neurobiological and ecological aspects are also included to provide intellectual breadth. The book uses examples that span the gamut from classical model organisms to non-model systems and human biology, and include both laboratory and field studies. Samples of historical information accentuate the text to provide the reader with an appreciation of the history of the field.

This book will be a valuable resource for future generations of scientists who focus on the field of behavioral genetics.

  • Defines the emerging science of behavioral genetics
  • Engagingly written by two leading experts in behavioral genetics
  • Clear explanations of basic quantitative genetic, neurogenetic and genomic applications to the study of behavior
  • Numerous examples ranging from model organisms to non-model systems and humans
  • Concise overviews and summaries for each chapter

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Preface

Chapter 1: Introduction and Historical Perspective


Overview


The Rise of the Modern Field of Behavioral Genetics


The Modern Evolutionary Synthesis


The Rise of Molecular Genetics


A Brief History of Neuroscience


The Emergence of Behavioral Genetics


Summary


Study Questions


Recommended Reading


Chapter 2: Mechanisms of Neural Communication


Overview


Transmission of Information in the Nervous System


The Resting Membrane Potential


The Mechanism of the Action Potential


Ion Channels, G-protein-coupled Receptors, and Signal Transduction


Summary


Study Questions


Recommended Reading


Chapter 3: Functional Organization of the Nervous System


Overview


The Organization of the Mammalian Nervous System


Communication between the Brain and the Periphery


Organization of the Nervous System in Insects


Neurotransmitters


Summary


Study Questions


Recommended Reading


Chapter 4: Measuring Behavior: Sources of Genetic and Environmental Variation


Overview


Behavioral Assays


Controlling Experimental Variation


Sources of Variation in Behavior


Effects of Mutations on Behavioral Phenotypes


Environmental Variation


Gene
Environment Correlation and Interaction


Summary


Study Questions


Recommended Reading


Chapter 5: Mapping Genotype to Phenotype in Populations


Overview


Genes in Populations: Random Mating


Genes in Populations: Inbreeding


Quantitative Genetic Model


Summary


Study Questions


Recommended Reading


Chapter 6: Partitioning Phenotypic Variance and Heritability


Overview


Components of Variance in Random Mating Populations


Genotype-Environment Correlation and Interaction


Partitioning Phenotypic Variance


Heritability : The Concept


Controlling and Estimating Environmental Components of Variation


Summary


Study Questions


Recommended Reading


Chapter 7: Estimating Heritability


Overview


Phenotypic Resemblance between Relatives


Genetic Causes of Covariance between Relatives


Environmental Causes of the Relationship between Relatives


Heritability Estimates in Humans


Heritability in Other Populations


Estimates of Heritability for Behavioral Traits


Summary


Study Questions


Recommended Reading


Chapter 8: Quantitative Trait Locus Mapping


Overview


Linkage Mapping


Interval Mapping


Statistical Analysis


Association Mapping


Quantitative Trait Locus End Game


Summary


Study Questions


Recommended Reading


Chapter 9: Mutagenesis and Transgenesis


Overview


The Occurrence or Induction of Mutations


Homologous Recombination


Transposon -mediated Mutagenesis


The GAL4-UAS Binary Expression System in Drosophila


RNA Interference


Summary


Study Questions


Recommended Reading


Chapter 10: Genomics Approaches in Behavioral Genetics


Overview


Detecting Large-scale Gene Expression


Parallel Sequencing and Transcriptional Analysis


Plasticity of Transcriptional Profiles


Analysis of Whole-genome Expression Microarray


Defining Statistical Signifi cance Threshold


Identifying Genetic Networks


Summary


Study Questions


Recommended Reading


Chapter 11: Neurogenetics of Activity and Sleep


Overview


Locomotion


Genetics of Human Locomotion Disorders


Circadian Rhythms


Sleep


Summary


Study Questions


Recommended Reading


Chapter 12: Genetics of Social Interactions


Overview


Social Environment and the Genes-Brain-Behavior Paradigm


Social Cooperation and Fitness


Courtship and Mate Selection


Affiliative Behavior


Aggression and the Establishment of Social Hierarchies


Division of Labor: The Genetics of Social Structure


Aggregation Behavior


Summary


Study Questions


Recommended Reading


Chapter 13: Genetics of Olfaction and Taste


Overview


The Study of Olfaction


The Discovery of Odorant Receptors


Transgenic Approaches to Determine Odorant Receptor Response Profiles


Transgenic Approaches to Map Projection Patterns of Olfactory Sensory Neurons


The Use of Transgenic Reporter Genes to Visualize Odor Coding


Taste and Gustatory Receptors


Summary


Study Questions


Recommended Reading


Chapter 14: Learning and Memory


Overview


Forming Memories


Memory Formation: Cellular Mechanisms


Harnessing the Power of Genetics: Learning in Drosophila


Identifying Genetic Networks for Learning and Memory


Learning Disabilities


Neurodegeneration and Memory Impairment: Alzheimer's Disease


Summary


Study Questions


Recommended Reading


Chapter 15: Genetics of Addiction


Overview


Hallmarks of Addiction


Alcoholism


Linkage and Association Studies


Alcohol Sensitivity in Model Organisms


Alcohol-related Phenotypes in Rodent Models


Smoking


Drug Addiction


Summary


Study Questions


Recommended Reading


Chapter 16: Evolution of Behavior


Overview


Population Genetics and Evolution


Models of Evolution


Selection Models


Assessing Deviations from Neutrality


Behavior as a Vehicle for Evolution


Insect-Host Plant Interactions: An Example of Evolutionary Adaptation


Co-evolution of Sexual Communication Systems


Study Questions


Recommended Reading


Chapter 16: Evolution of Behavior


Overview


Population Genetics and Evolution


Models of Evolution


Selection Models


Assessing Deviations from Neutrality


Behavior as a Vehicle for Evolution


Insect-Host Plant Interactions: An Example of Evolutionary Adaptation


Co-evolution of Sexual Communication Systems


The Evolutionary Genetics of Burrowing and Nest Building


The Astounding Diversity of Cichlids and Sticklebacks


Understanding the Evolution of Behavior: How Much Do We Really Know?


Summary


Study Questions


Recommended Reading


Glossary


Index


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Anholt, Robert RH
Mackay, Trudy F. C.
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