Programmed Cell Death, Volume I, critically details the molecular, biochemical and cellular mechanisms of apoptosis. This volume covers programmed cell death in a variety of tissues and organ systems highlighting the interesting families of proteins involved in promoting or preventing apoptosis. These include the caspase and calpain families of proteases, Bcl-2 family members, and inhibitors of apoptosis proteins. Each chapter is written by an internationally recognized expert in a particular aspect of programmed cell death.
This book will provide the reader with a comprehensive understanding of the cascade of events leading from an apoptotic signal, such as trophic factor withdrawal or increased oxidative stress, to cell death. Importantly, this volume also covers signaling mechanisms designed to prevent apoptosis. Such anti-apoptotic signaling cascades involve neurotrophic factors and stress response pathways. Programmed Cell Death, Volume I, provides the molecular and cellular foundation for [external URL] Cell Death, Volume II in which the roles of aberrant regulation of apoptosis in human diseases ranging from cancer to Alzheimer's disease are considered.
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Mechanisms Underlying the Hallmark Features of the
Execution-phase of Apoptosis
Death Domain Signaling and Its Role in the Central Nervous System
Diversity of Caspase Involvement in Neuronal Cell Death
Mitochondrial Control of Apoptosis
(B. Mignotte, J.-L. Vayssiere).
Proliferative Mitochondrial Dysfunction and Apoptosis
(M. Mancini, S. Camilleri-Broet,
B.O. Anderson, D.M. Hockenbery).
The Bcl-2 Family of Proteins and their Actions within
The Molecular Machinery of Cell Death
(Qing Guo, Sic L. Chan, I. Kruman).
The Role of Jun-Kinases in Apoptosis
(S.P. Tammariello, G.E. Landreth, S. Estus).
Apoptosis by Par-4 Protein
Cytoskeletal Involvement in Apoptosis
(R.K. Srivastava, D.L. Longo).
Anti-apoptotic Role of the Transcription Factor NF-kB
Inhibitor of Apoptosis Proteins (IAPS)
(Q.L. Deveraux, J.C. Reed).
Excitotoxins, Nitric Oxide and Programmed Neuronal Death
(M. Leist, P. Nicotera).