Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.
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1 mGlu4 Modulators Kevin Liu 2 Recent Advances towards Pain Therapeutics Philippe Nantermet 3 Circadian Rythym Paul Galatsis 4 Recent Progress in the Discovery of Kv7.x Modulators' Ismet Dorange 5 Bile Acid Receptor Modulators for Treatment of Metabolic Diseases Yanping Xu 6 Mineralocorticoid Receptor Antagonists Katerina Leftheris 7 SGLT2 Inhibitors for the Treatment of Diabetes Jiwen Liu, TaeWeon Lee 8 CRTh2 Antagonists Laurence E. Burgess 9 Developments and Advances in Gastrointestinal Prokinetic Agents James W. Dale 10 Targeting Th17 and Treg Signaling Pathways in Autoimmunity Shomir Ghosh 11 Advances in the Discovery of C5a Receptor Antagonists Jay P. Powers 12 Inhibition of Translation Initiation as a Novel Paradigm for Cancer 13 The Development of Inhibitor of Apoptosis Protein Antagonists for the Treatment of Resistant Cancers. Stephen Condon 14 Case History on the Discovery of Halaven® Melvin Lu 15 Emerging New Therapeutics against Key Gram-negative Pathogens Daniel Obrecht 16 Hepatitis C Virus Inhibitors
Beyond NS3 Protease and NS5B 17 The Emergence of Small Molecule Modulators of the Capsid Assembly Pathway as Potential Antiviral Therapeutics Clarence R. Hurt 18 Mechanism of Action (MoA) in Drug Discovery David Swinney 19 Aryl Hydrocarbon Receptor (AhR) Activation: An Emerging 20 Prolyl Isomerases Pat Flaherty 21 Potential Therapeutic Applications of miRNA Graham Brock 22 Induced Pluripotent Stem Cells (iPSC) as Drug Discovery Tools and Human Disease Models Charles R. Johnson 23 Progress in Drug Repositioning: Old Drugs, New Opportunities Michael A. Walters 24 Deuterium in Drug Discovery and Development Scott L. Harbeson 25 Phospholipidosis Peter Bernstein 26 To Market, To Market 2010 Joanne Bronson