The first comprehensive, systematic review of cellular domains
Cellular domains play vital roles in a wide range of cellular functions. Defining cellular domains and understanding the molecular basis of their formation is essential to the study of cell functionality. This authoritative reference provides the most comprehensive analysis available on cellular domains, with emphasis on the definition and molecular composition of the domain as well as the functional implications of domain organization.
Each chapter focuses on a different domain and is supported by figures defining the domain. Highlighting the latest advances in the field, the book′s extensive coverage includes:
Membrane domains Cytoskeleton–induced meso–scale domains, Clathrin–coated pits, Caveolae, Lipid rafts, and Modeling membrane domains
Organellar domains Mitochondria, Endoplasmic reticulum, Golgi apparatus, Endosomes, Lysosomes and phagosomes, and Endoplasmic reticulum junctions
Cytoskeletal domains Actin cytoskeleton, Microvilli, Microtubules, Cilia, and Intermediate filaments
Adhesive and communicating domains Focal adhesions, Adherens junctions, Tight junctions and desmosomes, and Gap junctions
Polarized cellular domains Epithelial domains and Neuronal domains
Domains regulating gene expression Nuclear domains, Nuclear pore, and Cytoplasmic RNA domains
Such thorough coverage of the many and various cellular domains makes this a one–stop reference for research scientists as well as advanced students in cell biology, biochemistry, cellular biophysics, and cellular physiology.
PART I MEMBRANE DOMAINS.
CHAPTER 1 CYTOSKELETON–INDUCED MESOSCALE DOMAINS (Ziya Kalay, Takahiro K. Fujiwara, and Akihiro Kusumi).
CHAPTER 2 CLATHRIN–COATED PITS (James R. Thieman and Linton M. Traub).
CHAPTER 3 CAVEOLAE (Dan Tse and Radu V. Stan).
CHAPTER 4 LIPID RAFTS (Leonard J. Foster).
CHAPTER 5 MODELING MEMBRANE DOMAINS (Daniel Coombs, Raibatak Das, and Jennifer S. Morrison).
PART II ORGANELLAR DOMAINS.
CHAPTER 6 MITOCHONDRIA (Michael Zick and Andreas S. Reichert).
CHAPTER 7 THE ENDOPLASMIC RETICULUM (Jody Groenendyk and Marek Michalak).
CHAPTER 8 THE GOLGI APPARATUS (James W. Dennis and Ivan R. Nabi).
CHAPTER 9 ENDOSOMES (Thierry Galvez and Marino Zerial).
CHAPTER 10 LYSOSOMES AND PHAGOSOMES (Guillaume Goyette and Michel Desjardins).
CHAPTER 11 ENDOPLASMIC RETICULUM JUNCTIONS (Jesse T. Chao and Christopher J.R. Loewen).
PART III CYTOSKELETAL DOMAINS.
CHAPTER 12 THE ACTIN CYTOSKELETON (Jonathan A. Kelber and Richard L. Klemke).
CHAPTER 13 MICROVILLI (Florent Ubelmann, Sylvie Robine, and Daniel Louvard).
CHAPTER 14 MICROTUBULES (Geoffrey O. Wasteneys and Bettina Lechner).
CHAPTER 15 CILIA (Laura K. Hilton and Lynne M. Quarmby).
CHAPTER 16 INTERMEDIATE FILAMENTS (Normand Marceau, Anne Loranger, Stéphane Gilbert, and François Bordeleau).
PART IV ADHESIVE AND COMMUNICATING DOMAINS.
CHAPTER 17 FOCAL ADHESIONS (Caitlin Tolbert and Keith Burridge).
CHAPTER 18 THE ADHERENS JUNCTION (Christopher P. Toret and W. James Nelson).
CHAPTER 19 SPECIALIZED INTERCELLULAR JUNCTIONS IN EPITHELIAL CELLS: THE TIGHT JUNCTION AND DESMOSOME (Keli Kolegraff, Porfi rio Nava, and Asma Nusrat).
CHAPTER 20 GAP JUNCTIONS (Jared M. Churko and Dale W. Laird).
PART V POLARIZED CELLULAR DOMAINS.
CHAPTER 21 EPITHELIAL DOMAINS (Nancy Philp, Liora Shoshani, Marcelino Cereijido, and Enrique Rodriguez–Boulan).
CHAPTER 22 NEURONAL DOMAINS (Jennifer S. Goldman and Timothy E. Kennedy).
PART VI DOMAINS REGULATING GENE EXPRESSION.
CHAPTER 23 NUCLEAR DOMAINS (Dale Corkery, Kendra L. Cann, and Graham Dellaire).
CHAPTER 24 THE NUCLEAR PORE (Richard W. Wozniak, Christopher Ptak, and John D. Aitchison).
CHAPTER 25 CYTOPLASMIC RNA DOMAINS (Henry Parker and Tom C. Hobman).
Dr. Ivan R. Nabi received his BSc in biochemistry at McGill University in 1983 and his PhD in cancer metastasis at the Weizmann Institute of Science in 1989. After completing his post–doctoral training in cell biology at Cornell University Medical College, he joined the Université de Montréal, where he became Full Professor in the Department of Pathology and Cell Biology. In 2004, Dr. Nabi moved to the University of British Columbia, where he is now a Professor in the Department of Cellular and Physiological Sciences. Research in Dr. Nabi′s lab is focused on the cell biology of cancer; he studies a number of cellular domains including lipid rafts and caveolae, the endoplasmic reticulum, focal adhesions, and tumor cell pseudopodia.