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Biocatalysis for Green Chemistry and Chemical Process Development

  • ID: 1935007
  • Book
  • 496 Pages
  • John Wiley and Sons Ltd
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Biocatalysis for Green Chemistry and Chemical Process Development offers an exciting alternative to today′s complex, multidisciplinary approach to green chemistry by focusing exclusively on the most potent weapon in this field′s arsenal biocatalysis. In–depth coverage details the technological advances being made in biocatalysis–driven green syntheses of industrially important molecules, as well as how these advances show great promise in streamlining current chemical processes for reducing or eliminating hazardous substances. In addition, coverage of the biotechnological production of pharmaceuticals (small molecules, natural products and biologics), flavors, fragrance and cosmetics, fine chemicals, and more underscore the book′s main goal of facilitating industrial applications of this powerful and pioneering green technology. Highlights include:

  • A variety of case studies, not only in pharmaceuticals and fine chemicals, but also specialty and bulk chemicals and polymers

  • A comprehensive overview of green chemistry applications of enzyme–driven transformations for a wide range of industries

  • A look at the application of biocatalysis across a wide range of chemical manufacturing fields, and why it is a good sustainable manufacturing option

Biocatalysis is emerging as a transformational technology uniquely suited to deliver green chemistry solutions for safer, efficient, and more cost–effective chemical synthesis. Biocatalysis for Green Chemistry and Chemical Process Development serves a key role in promoting this significant and potentially world–changing technology and offers valuable perspective on achieving widespread sustainable industrial practices.

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Contributors vii

Preface xi

Part I. Introduction Chapters 1

1. Biotechnology Tools for Green Synthesis: Enzymes, Metabolic Pathways, and Their Improvement by Engineering 3

2. How Green Can the Industry Become with Biotechnology? 23

3. Emerging Enzymes and Their Synthetic Applications 45

4. Reaction Efficiencies and Green Chemistry Metrics of Biotransformations 67

Part II. Application and Case Studies–Pharmaceuticals and Fine Chemicals 89

5. Biocatalytic Routes to Chiral Intermediates for Development of Drugs 91

6. Transglutaminase for Protein Drug Modification: Pegylation and Beyond 151

7. Microbial Production of Plant–Derived Pharmaceutical Natural Products Through Metabolic Engineering: Artemisinin and Beyond 173

8. Toward Greener Therapeutic Proteins 197

Part III. Application and Case Studies–Flavor & Fragrance, Agrochemicals and Fine Chemicals 221

9. Opportunities for Biocatalysis in the Flavor, Fragrance, and Cosmetic Industry 223

10. Application of Biocatalysis in the Agrochemical Industry 255

11. Green Porduction of Fine Chemicals by Isolated Enzymes 277

12. Whole Cell Production of Fine Chemicals and Intermediates 299

Part IV. Application and Case Studies–Polymers and Renewable Chemicals 327

13. Green Chemistry for the Production of Biodegradable, Biorenewable, Biocompatible, and Polymers 329

14. Enzymatic Degradation of Lignocellulosic Biomass 361

15. Bioconversion of Nenewables–Plant Oils 391

16. Microbial Bioprocesses for industrial–Scale Chemical Production 429

Index 469  

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Junhua (Alex) Tao
Romas Joseph Kazlauskas
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