This valuable resource provides simple explanations of the ways in which biological systems use basic biochemical mechanisms to produce fine chemical control of physiology, allowing for more informed predictions of drug effects in all systems and forming the basis of the drug-discovery process. Chapters follow a logical progression on how to characterize the pharmacology of any given molecule, and include important terminology, chapter summaries, references, and review questions to aid the reader in understanding and retention of the material.
- Enables the reader to interpret drug dose-response data and make mechanistic inferences at the molecular level- Bridges the gap between biochemistry and therapeutic medicine- Chapters include key topics such as drug affinity and efficacy, enzymes as drug targets, in vivo pharmacology, safety pharmacology, and more
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Chapter 1: Pharmacology: The Chemical Control of Physiology
Chapter 2: Drug Affinity and Efficacy
Chapter 3: Predicting Agonist Effect
Chapter 4: Drug Antagonism: Orthosteric Drug Effects
Chapter 5: Allosteric Drug Effects
Chapter 6: Enzymes as Drug Targets
Chapter 7: Pharmacokinetics I: Permeation and Metabolism
Chapter 8: Pharmacokinetics II: Distribution and Multiple Dosing
Chapter 9: In Vivo Pharmacology
Chapter 10: Safety Pharmacology
Chapter 11: Answers to Chapter Questions
Chapter 12: Derivations and Proofs
Terry P. Kenakin is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society. Having been involved in drug discovery for over 30 years, his interests include the optimal design of drug activity assays systems and quantitative drug receptor theory. He is a member of numerous editorial boards as well as Editor-in-Chief of the Journal of Receptors and Signal Transduction and Current Opinion in Pharmacology. In addition, Dr. Kenakin has authored numerous articles and has also written a number of books on pharmacology.