Mass Spectrometry in Polymer Chemistry

  • ID: 2093699
  • Book
  • 500 Pages
  • John Wiley and Sons Ltd
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Mass spectrometry is a powerful analytical tool for the determination of the chemical composition, structure and molecular weight of organic compounds. Already widely used in the life sciences, mass spectrometry has become an indispensable characterization method in polymer chemistry – in basic research as well as in industrial laboratory settings. Mass spectrometry can be integrated seamlessly with other analytical techniques such as liquid chromatography. Its sensitivity and specifity make it a versatile means for the qualitative and quantitative elucidation of polymer composition, functionality and reaction mechanisms.

Combining an up–to–date insight into mass spectrometry polymer analysis beyond MALDI with application details of the instrumentation, this is a balanced and thorough presentation of the most important and widely used mass spectrometric methods. The book provides the state–of–the–art knowledge on mass spectrometry for the synthetically working chemist, enabling the researcher to choose the appropriate methods and instrumentations – and to assess their respective strenghths and limitations – for the characterization of polymer compounds.

Written by the world′s most proficient experts in the field, the book focuses on the latest developments, covering important technologies and applications such as ionization protocols, tandem and liquid chromatography mass spectrometry, gas–phase ion–separations, secondary ion mass spectrometry and automated data processing.

This book is a must–have for all Polymer and Analytical Chemists, Materials Scientists, Spectroscopists, and Chemists in Industry.
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Introduction

MASS ANALYSIS

Introduction

Measures of Performance

Instrumentation

Instrumentation in Tandem and Multiple–Stage Mass Spectrometry

Conclusions and Outlook

IONIZATION TECHNIQUES FOR POLMYER MASS SPECTROMETRY

Introduction

Small Molecule Ionization Era

Macromass Era of Ionization

Modern Era of Ionization Techniques

Conclusions

TANDEM MASS SPECTROMETRY ANALYSIS OF POLYMER STRUCTURES AND ARCHITECTURES

Introduction

Activation Methods

Instrumentation

Structural Information from MS2 Studies

Summary and Outlook

MATRIX–ASSISTED INLET IONIZATION AND SOLVENT–FREE GAS–PHASE SEPARATION USING ION MOBILITY SPECTROMETRY FOR IMAGING AND ELECTRON TRANSFER DISSOCIATION MASS SPECTROMETRY OF POLYMERS

Overview

Introduction

New Sample Introduction Technologies

Fragmentation by ETD and CID

Surface Analyses by Imaging MS

Future Outlook

POLYMER MALDI SAMPLE PREPARATION

Introduction

Roles of the Matrix

Choice of Matrix

Choice of the Solvent

Basic Solvent–Based Sample Preparation Recipe

Deposition Methods

Solvent–Free Sample Preparation

The Vortex Method

Matrix–to–Analyte Ratio

Salt–to–Analyte Ratio

Chromatography as Sample Preparation

Problems in MALDI Sample Preparation

Predicting MALDI Sample Preparation

Conclusions

SURFACE ANALYSIS AND IMAGING TECHNIQUES

Imaging Mass Spectrometry

Secondary Ion Mass Spectrometry

Matrix–Assisted Laser Desorption Ionization (MALDI)

Other Surface Mass Spectrometry Methods

Outlook

HYPHENATED TECHNIQUES

Introduction

Polymer Separation Techniques

Principles of Coupling: Transfer Devices

Examples

Conclusions

AUTOMATED DATA PROCESSING AND QUANTIFICATION IN POLMYER MASS SPECTROMETRY

Introduction

File and Data Formats

Optimization of Ionization Conditions

Automated Spectral Analysis and Data Reduction in MS

Copolymer Analysis

Data Interpretation in MS/MS

Quantitative MS and the Determination of MMDs by MS

Conclusions and Outlook

COMPREHENSIVE COPOLYMER CHARACTERIZATION

Introduction

Scope

Reviews

Soft Ionization Techniques

Separation Prior MS

Tandem MS (MS/MS)

Quantitative MS

Copolymers for Biological or (Bio)medical Application

Software Development

Summary and Outlook

ELUCIDATION OF REACTION MECHANISMS: CONVENTIONAL RADICAL POLYMERIZATION

Introduction

Basic Principles and General Considerations

Initiation

Propagation

Termination

Chain Transfer

Emulsion Polymerization

Conclusion

ELUCIDATION OF REACTION MECHANISMS AND POLYMER STRUCTURE: LIVING/CONTROLLED RADICAL POLYMERIZATION

Protocols Based on a Persistent Radical Effect (NMP, ATRP, and Related)

Protocols Based on Degenerative Chain Transfer (RAFT, MADIX)

Protocols Based on CCT

Novel Protocols and Minor Protocols

Conclusions

ELUCIDATON OF REACTION MECHANISMS: OTHER POLYMERIZATION MECHANISMS

Introduction

Ring–Opening Polymerization Mechanisms of Cyclic Ethers

Ring–Opening Polymerization Mechanisms of Cyclic Ethers and Carbonates

Ring–Opening Metathesis Polymerization

Mechanisms of Step–Growth Polymerization

Concluding Remarks

POLYMER DEGRADATION

Introduction

Thermal and Thermo–Oxidative Degradation

Photolysis and Photooxidation

Biodegradation

Other Degradation Processes

Conclusions

OUTLOOK
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Taken as a whole, this book gives an excellent overview of the current state of mass spectrometry being applied to modern, complex polymer systems.   (Chromatographia, 1 August 2013)

There is much to laud the editors for the production of this work . . . As the editors have so clearly achieved their stated goals, it is easy to be enthusiastic about this volume and to recommend it to anyone interested in polymer chemistry or mass spectrometry as a needed resource.   (American Society for Mass Spectrometry, 11 August 2012)

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