Advanced Therapy for Hepatitis C

  • ID: 2096059
  • Book
  • 232 Pages
  • John Wiley and Sons Ltd
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According to the WHO, 170 million people, or 3% of the world′s population, are infected with Hepatitis C and at risk of developing liver cirrhosis and/or liver cancer.   3–4 million people each year are newly diagnosed carriers of the virus.

Advanced Therapy for Hepatitis C Infection provides you with expert guidance from the world s leading hepatologists on the very latest treatment options for patients with the HCV virus.  Focusing mainly on the efficacy and clinical use of antiviral therapies, key topics include:

  • Treatment of recurrent hepatitis C following liver transplantation
  • Antivirals in Cirrhosis and Portal Hypertension
  • HIV and Hepatitis C co–infection
  • Cytopenias: how they limit therapy and potential correction
  • The problem of insulin resistance and its effect on therapy
  • Antivirals in Acute Hepatitis C

In addition, it fully covers the foundations for understanding antiviral therapies in HCV, such as the complex pharmacology and mechanisms of antiviral drugs.  Finally, a chapter on New Horizons:  Interleukin 28 and direct–acting antiviral therapy for HCV, offers you a glimpse into the future possibilities for HCV therapy.   

Edited by a team of outstanding international reputation, Advanced Therapy for Hepatitis C Infection is an essential tool for all hepatologists and gastroenterologists involved in the management of patients with Hepatitis C.

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Contributors vii

Preface xi

Section I Foundations for Understanding Antiviral Therapies in HCV

1 HCV Replication 3Michael R. Beard2 Hepatitis C Virus Genotypes 12Scott A. Read and Mark W. Douglas3 Immune Responses to HCV: Implications for Therapy 17David G. Bowen4 Mechanisms of Action of Antiviral Drugs: The Interferons 25Edmund Tse and Michael R. Beard5 Pharmacology and Mechanisms of Action of Antiviral Drugs: Ribavirin Analogs 36Fred Poordad and Grace M. Chee6 Pharmacology and Mechanisms of Action of Antiviral Drugs: Polymerase Inhibitors 43Lotte Coelmont Leen Delang Mathy Froeyen Piet Herdewijn and Johan Neyts7 Pharmacology and Mechanisms of Action of Antiviral Drugs: Protease Inhibitors 53Laurent Chatel–Chaix Martin Baril and Daniel Lamarre8 Measuring Antiviral Responses 60Jean–Michel Pawlotsky and Stephane ChevaliezSection II Efficacy and Clinical Use of Antiviral Therapies

9 Genotype 1: Standard Treatment 67Rebekah G. Gross and Ira M. Jacobson10 Individually Tailored Treatment Strategies in Treatment–na¨ive Chronic Hepatitis C Genotype 1 Patients 74Johannes Wiegand and Thomas Berg11 Genotype 1 Relapsers and Non–responders 84Salvatore Petta and Antonio Craxì12 Standard Therapy for Genotypes 2/3 90Kenneth Yan and Amany Zekry13 Altered Dosage or Durations of Current Antiviral Therapy for HCV Genotypes 2 and 3 97Alessandra Mangia Leonardo Mottola and Angelo Andriulli14 Genotypes 2 and 3 Relapse and Non–response 104
Stella Mart´inez Jose Maria Sanchez–Tapias and Xavier Forns

15 Hepatitis C Genotype 4 Therapy: Progress and Challenges 113Sanaa M. Kamal16 Antivirals in Acute Hepatitis C 127Heiner Wedemeyer17 Antivirals in Cirrhosis and Portal Hypertension 132Diarmuid S. Manning and Nezam H. Afdhal18 Treatment of Recurrent Hepatitis C Following Liver Transplantation 140Ed Gane19 Antiviral Treatment in Chronic Hepatitis C Virus Infection with Extrahepatic Manifestations 150Benjamin Terrier and Patrice Cacoub20 Cytopenias: How they Limit Therapy and Potential Correction 160Mitchell L. Shiffman21 The Problem of Insulin Resistance and its Effect on Therapy 169Venessa Pattullo and Jacob George22 HIV and Hepatitis C Co–infection 177Gail V. Matthews and Gregory J. Dore23 HCV and Racial Differences 185Andrew J. Muir24 HCV and the Pediatric Population 190Kathleen B. Schwarz25 New Horizons: IL28 Direct–acting Antiviral Therapy for HCV 196Alexander J. Thompson John G. McHutchison and Geoffrey W. McCaughanIndex 215

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I think it is an invaluable respository of knowledge for anyone embarking on a career caring for patients with viral hepatitis. This book summarises the hard won clinical knowledge of the past 20 years.   (The Irish Medical Journal, 1 January 2013)

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