Pharmacogenetics and Individualized Therapy

  • ID: 2105787
  • Book
  • 502 Pages
  • John Wiley and Sons Ltd
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The one–stop reference to pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practices

Pharmacogenetics and Individualized Therapy offers thorough coverage of the study of the genetic determinants of drug response at the single gene level—and its impact on pharmaceuticals, therapeutics, and clinical practice. Providing an overview of the molecular basis of pharmacogenetics, the book helps readers understand the implications of genetic variability on pharmacokinetics and pharmacodynamics, as well as other aspects such as adverse drug reactions. Providing coverage of specific disease areas, including cardiovascular concerns, cancer and asthma/COPD, transplantation, and pain medication, the book also looks at the clinical practices, along with the psychiatric and ethical issues that have come to dominate conversation about pharmacogenetics.

The technological applications of pharmacogenetics, including genotyping, drug disposition (metabolism and enzymes), and the impact of this research on the pharmaceutical industry and regulatory matters are all addressed in chapters by internationally recognized leaders from both academia and industry.

Including chapters on specific therapeutic areas and clinical aspects, Pharmacogenetics and Individualized Therapy helps readers, whether they′re students or researchers, to understand the implications of genetic variability on pharmacokinetics and pharmacodynamics.

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PREFACE vii

CONTRIBUTORS ix

1. Pharmacogenetics: A Historical Perspective 1Ann K. Daly

PART I PHARMACOGENETICS: RELATIONSHIP TO PHARMACOKINETICS AND PHARMACODYNAMICS

2. Pharmacogenetics in Drug Metabolism: Role of Phase I Enzymes 15Vita Dolz¡an

3. Pharmacogenetics of Phase II Drug Metabolizing Enzymes 81Ingolf Cascorbi

4. Pharmacogenetics of Drug Transporters 101Henriette E. Meyer zu Schwabedissen, Markus Grube, and Heyo K. Kroemer

5. Pharmacogenetics of Drug Targets 149Ann K. Daly and Maria Arranz

PART II PHARMACOGENETICS: THERAPEUTIC AREAS

6. Cardiovascular Pharmacogenetics 185Bas J. M. Peters, Anthonius de Boer, Tom Schalekamp, Olaf H. Klungel, and Anke–Hilse Maitland–van der Zee

7. Pharmacogenetics in Psychiatry 215Evangelia M. Tsapakis, Sarah Curran, Ruth I. Ohlsen, Nora S. Vyas, Katherine J. Aitchison, and Ann K. Daly

8. Pharmacogenetics in Cancer 251Sharon Marsh

9. Pharmacogenetics of Asthma and COPD 271Ellen S. Koster, Jan A. M. Raaijmakers, Anke–Hilse Maitland–van der Zee, and Gerard H. Koppelman

10. Pharmacogenetics of Adverse Drug Reactions 295Ann K. Daly, Martin Armstrong, and Munir Pirmohamed

11. Pharmacogenomics of Inflammatory Bowel Diseases 323Alexander Teml, Susanne Karner, Elke Schaeffeler, and Matthias Schwab

12. Pharmacogenetics of Pain Medication 353Jo¨rn Lo¨tsch

PART III PHARMACOGENETICS: IMPLEMENTATION IN CLINICAL PRACTICE

13. Ethical and Social Issues in Pharmacogenomics Testing 377Susanne Vijverberg, Toine Pieters, and Martina Cornel

PART IV DEVELOPMENTS IN PHARMACOGENETIC RESEARCH

14. High–Throughput Genotyping Technologies for Pharmacogenetics 403Beatriz Sobrino and Angel Carracedo

15. Developments in Analyses in Pharmacogenetic Datasets 415Alison A. Motsinger–Reif

PART V PHARMACOGENETICS: INDUSTRY AND REGULATORY AFFAIRS

16. Applications of Pharmacogenetics in Pharmaceutical Research and Development 439Daniel K. Burns and Scott S. Sundseth

17. Role of Pharmacogenetics in Registration Processes 461Myong–Jin Kim, Issam Zineh, Shiew–Mei Huang, and Lawrence J. Lesko

PART VI CONCLUSIONS

18. Pharmacogenetics: Possibilities and Pitfalls 479Anke–Hilse Maitland–van der Zee and Ann K. Daly

INDEX 485

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Anke–Hilse Maitland–van der Zee
Ann K. Daly
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