Syntheses requiring high material throughput are made even more challenging when targeting pure enantiomers. Asymmetric reactions employing chiral catalysts and prochiral substrates are highly attractive because one molecule of catalyst generates a multitude of chiral progeny. Modern synthesis is rapidly evolving by creating new transformations that employ C–H bonds as the locus for specific functionalization. This Handbook presents short, informative articles on some 80 reagents that summarize the current state–of–the–art using chiral strategies efficiently to increase molecular complexity. These transformations include arene and heteroarene functionalizations, the introduction of heteroatoms, the formation of chiral centers, rings and multiple bonds, and enantiogenesis.
All the information compiled in this volume is also available in electronic format on Wiley InterScience. The electronic Encyclopedia of reagents for Organic Synthesis (e–EROS)) includes all the reagents described here plus many more reagents of other types and for other uses. e–EROS offers text and structure search and is updated twice a year. For More information visit: <a href="[external URL]
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