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Tutorials in Biostatistics. Statistical Methods in Clinical Studies. Volume 1

  • ID: 2170385
  • Book
  • 464 Pages
  • John Wiley and Sons Ltd
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TheTutorials in Biostatistics series has become a very popular feature of the journal,Statistics in Medicine. The tutorials are accessible, self–contained and of a uniformly high quality. This book represents the first of two volumes presenting the best tutorials published in the journal, focusing on statistical methods in clinical studies. Topics include the design and analysis of clinical trials, epidemiology, survival analysis, and data monitoring. Each tutorial has been fully peer–reviewed and edited, and authored by leading researchers in biostatistics.
  • Presents a collection of tutorials in biostatistics, taken from the prestigious Wiley journal, Statistics in Medicine.
  • Focuses on methods in clinical studies, including epidemiology, survival analysis, design and analysis of clinical trials, and data monitoring.
  • Each tutorial has been fully peer reviewed and edited to ensure a high level of quality and to maintain the practical focus.
  • Suitable for medical practitioners with a good understanding of statistics.
  • Each tutorial has been authored by leading researchers in the field.

The Tutorials in Biostatistics volumes provide an authoritative and readable introduction to a wide range of topics suitable for statisticians working in medical research, as well as statistically–minded clinicians, biologists, epidemiologists, and geneticists. Graduate students of biostatistics will find they make excellent reference volumes to support their study.

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Preface to Volume 1.


1.1 Epidemiology.

Computing Estimates of Incidence, including Lifetime Risk: Alzheimer s Disease in the Framingham Study. The Practical Incidence Estimators (PIE) Macro. (Alexa Beiser et al).

The Applications of Capture–Recapture Models to Epidemiological Data. (Anne Chao et al).

1.2 Adjustment Methods.

Propensity Score Methods for Bias Reduction in the Comparison of a Treatment to a Non–Randomized Control Group (Ralph B. D Agostino Jr.).

1.3 Agreement Statistics.

Kappa Coefficients in Medical Research (Helen Chmura Kraemer et al).

1.4 Survival Models.

Survival Analysis in Observational Studies (Kate Bull and David J. Spiegelhalter).

Methods for Interval–Censored Data (Jane C. Lindsey and Louise M. Ryan).

Analysis of Binary Outcomes in Longitudinal Studies Using Weighted Estimating Equations and Discrete–Time Survival Methods: Prevalence and Incidence of Smoking in an Adolescent Cohort (John B. Carlin et al).


2.1 Prognostic Variables.

Categorizing a Prognostic Variable: Review of Methods, Code for Easy Implementation and Applications to Decision–Making about Cancer Treatments (Madhu Mazumdar and Jill R. Glassman).

2.2 Prognostic/Clinical Prediction Models.

Development of Health Risk Appraisal Functions in the Presence of Multiple Indicators: The Framingham Study Nursing Home Institutionalization Model (R. B. D Agostino et al).

Multivariable Prognostic Models: Issues in Developing Models, Evaluating Assumptions and Adequacy, and Measuring and Reducing Errors (Frank E. Harrell Jr et al).

Development of a Clinical Prediction Model for an Ordinal Outcome: The World Health Organization Multicentre Study of Clinical Signs and Etiological Agents of Pneumonia, Sepsis and Meningitis in Young Infants (Frank E. Harrell Jr. et al).

Using Observational Data to Estimate Prognosis: An Example Using a Coronary Artery Disease Registry (Elizabeth R. DeLong et al).


3.1 Design.

Designing Studies for Dose Response (Weng Kee Wong and Peter A. Lachenbruch.).

3.2 Monitoring.

Bayesian Data Monitoring in Clinical Trials (Peter M. Fayers et al).

3.3 Analysis.

Longitudinal Data Analysis (Repeated Measures) in Clinical Trials (Paul S. Albert).

Repeated Measures in Clinical Trials: Simple Strategies for Analysis Using Summary Measures (Stephen Senn et al).

Strategies for Comparing Treatments on a Binary Response with Multi–Centre Data (Alan Agresti, and Jonathan Hartzel).

A Review of Tests for Detecting a Monotone Dose Response Relationship with Ordinal Response Data (Christy Chuang–Stein and Alan Agresti).

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Ralph B. D′Agostino
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