Medical Biochemistry. Human Metabolism in Health and Disease

  • ID: 2170619
  • Book
  • 440 Pages
  • John Wiley and Sons Ltd
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Helps Readers Understand The Link Between Metabolic Pathways And Human Health And Disease

Medical Biochemistry enables readers to master the essentials of human metabolism by explaining how metabolic pathways and reactions are connected to human health and disease. Rather than cover all the reactions that human cells and tissues are capable of executing, this text better enables readers to learn core concepts by emphasizing select examples that illustrate the physiologic and pathophysiologic significance of the major metabolic pathways. Designed for medical, dental, and allied health students and professionals, the text emphasizes clinically relevant information, helping readers understand the interrelationships between metabolic pathways and the links between metabolism and the causes, preventions, and cures for human diseases.

A separate chapter is dedicated to each of the key metabolic pathways that constitute human metabolism. Each chapter features a six–part structure that facilitates a clear understanding of the metabolic processes:

  • Major function(s) of the pathway

  • Tissues in which the pathway is active

  • Physiological conditions under which the pathway is most active

  • Reactions that comprise the pathway

  • Regulation of the pathway

  • Examples of human diseases related to the pathway

Throughout the text, simple figures help readers understand how metabolic pathways and reactions work.

This text′s concise, easy–to–follow approach helps readers understand and appreciate the functions, constituent reactions, and regulatory aspects of the core pathways that constitute human metabolism and are responsible for maintaining homeostasis and well–being in humans.

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PREFACE vii

ACKNOWLEDGMENTS ix

THE AUTHORS xi

1 INTRODUCTION TO METABOLISM 1

2 ENZYMES 11

3 DIGESTION AND ABSORPTION 38

4 GLYCOLYSIS 58

5 PYRUVATE DEHYDROGENASE AND THE TRICARBOXYLIC ACID CYCLE 77

6 ELECTRON TRANSPORT AND OXIDATIVE PHOSPHORYLATION 89

7 THE PENTOSE PHOSPHATE PATHWAY 102

8 GLYCOGEN 112

9 GLUCONEOGENESIS 126

10 FATTY ACID OXIDATION AND KETONES 141

11 FATTY ACID SYNTHESIS 162

12 TRIACYLGLYCEROL TRANSPORT AND METABOLISM 177

13 ETHANOL 191

14 PHOSPHOLIPIDS AND SPHINGOLIPIDS 199

15 EICOSANOIDS 218

16 GLYCOLIPIDS AND GLYCOPROTEINS 231

17 CHOLESTEROL SYNTHESIS AND TRANSPORT 246

18 STEROIDS AND BILE ACIDS 271

19 NITROGEN HOMEOSTASIS 290

20 AMINO ACIDS 305

21 SULFUR AMINO ACID METABOLISM 325

22 FOLATE AND VITAMIN B12 IN ONE–CARBON METABOLISM 335

23 PURINES AND PYRIMIDINES 351

24 HEME AND IRON 372

25 INTEGRATION OF METABOLISM 393

INDEX 411

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"All the necessary topics are accurately covered, with ample formulae and metabolic pathways, and reasonable clinical references." (ACP News, June 2009)
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