Today, treatment options for cancer patients typically include surgery, radiation therapy, immunotherapy, and chemotherapy. While these therapies have saved lives and reduced pain and suffering, cancer still takes millions of lives every year around the world. In recent years, researchers have been working on a new strategy: developing microbes and microbial products that specifically attack cancer cells.
This book breaks new ground in emerging cancer treatment modalities by presenting recent advances in the use of microorganisms and viruses as well as their products in cancer therapy. Seventeen chapters review the application of live microorganisms, high and low molecular weight products derived from microorganisms, and microbial products fused to cancer–targeting molecules. In addition, the book highlights the benefits of a multi–target approach to destroy cancer cells. Readers will not only discover the results and significance of basic and clinical research, but also encouraging results from clinical trials.
Emerging Cancer Therapy is divided into three sections:
Section 1: Live/Attenuated Bacteria and Viruses as Anticancer Agents
Section 2: Bacterial Products as Anticancer Agents
Section 3: Patents on Bacteria/Bacterial Products as Anticancer Agents
With chapters written by leading pioneers in microbial, biotech, and cancer research, Emerging Cancer Therapy is recommended for biotechnologists, microbiologists, clinical oncologists, medicinal chemists, and biochemists. Readers will not only learn the tremendous potential of microbial and biotechnological approaches to cancer therapy, but also discover new directions of research for effective drug discovery and development.
PART I LIVE/ATTENUATED BACTERIA AND VIRUSES AS ANTICANCER AGENTS.
1 Salmonella Typhimurium Mutants Selected to Grow Only in Tumors to Eradicate Them in Nude Mouse Models (Robert M. Hoffman).
2 The Use of Living Listeria Monocytogenes as an Active Immunotherapy for the Treatment of Cancer (John Rothman, Anu Wallecha, Paulo Cesar Maciag, Sandra Rivera, Vafa Shahabi, and Yvonne Paterson).
3 Bacillus Calmette Guerin (BCG) for Urothelial Carcinoma of the Bladder (Timothy P. Kresowik and Thomas S. Griffith).
4 Live Clostridia: A Powerful Tool in Tumor Biotherapy (Lieve Van Mellaert, Ming Q Wei, and Jozef Anné).
5 Bifi dobacterium as a Delivery System of Functional Genes for Cancer Gene Therapy (Geng–Feng Fu, Yan Yin, Bi Hu, and Gen–Xing Xu).
6 Replication–Selective Viruses for the Treatment of Cancer (Padma Sampath and Steve H. Thorne).
7 Engineering Herpes Simplex Virus for Cancer Oncolytic Virotherapy (Jason S. Buhrman, Tooba A. Cheema, and Giulia Fulci).
PART II BACTERIAL PRODUCTS AS ANTICANCER AGENTS.
8 Promiscuous Anticancer Drugs from Pathogenic Bacteria: Rational Versus Intelligent Drug Design (Arsénio M. Fialho and Ananda M. Chakrabarty).
9 Arginine Deiminase and Cancer Therapy (Lynn Feun, M. Tien Kuo, Ming You, Chung Jing Wu, Medhi Wangpaichitr, and Niramol Savaraj).
10 Cytosine Deaminase/5–Fluorocytosine Molecular Cancer Chemotherapy (Sergey A. Kaliberov and Donald J. Buchsbaum).
11 Bacterial Proteins Against Metastasis (Anna Maria Elisabeth Walenkamp).
12 Pseudomonas Exotoxin A–Based Immunotoxins for Targeted Cancer Therapy (Philipp Wolf and Ursula Elsässer–Beile).
13 Denileukin Diftitox in Novel Cancer Therapy (Lin–Chi Chen and Nam H. Dang).
14 The Application of Cationic Antimicrobial Peptides in Cancer Treatment: Laboratory Investigations and Clinical Potential (Ashley L. Hilchie and David W. Hoskin).
15 Prodiginines and Their Potential Utility as Proapoptotic Anticancer Agents (Neil R. Williamson, Suresh Chawrai, Finian J. Leeper, and George P.C. Salmond).
16 Farnesyltransferase Inhibitors of Microbial Origins in Cancer Therapy (Jingxuan Pan and Sai–Ching Jim Yeung).
17 The Use of RNA and CpG DNA as Nucleic Acid–Based Therapeutics (Jörg Vollmer).
PART III PATENTS ON BACTERIA/BACTERIAL PRODUCTS AS ANTICANCER AGENTS.
18 The Role and Importance of Intellectual Property Generation and Protection in Drug Development (Arsénio M. Fialho and Ananda M. Chakrabarty).
ANANDA CHAKRABARTY, PhD, is Distinguished University Professor in the Department of Microbiology and Immunology at the University of Illinois College of Medicine at Chicago. In addition to more than 250 research publications, he has secured nine U.S. patents during the last four years on azurin and Laz, two bacterial proteins with anticancer, anti–viral and anti–parasitic activities. He also is the recipient of a patent on the first life form, a genetically manipulated pseudomonad designed to degrade multiple hydrocarbons present in crude oil, as decided by the U.S. Supreme Court in 1980 in the celebrated court case Diamond v. Chakrabarty.