Lyme borreliosis, popularly known as Lyme disease, remains the most commonly reported tick–transmitted infection in North America and Europe. A growing body of scientific and clinical evidence has facilitated early diagnosis and effective treatment. Nonetheless, there are a number of misconceptions about this infectious disease that have given rise to unproven, potentially dangerous alternative therapies. In Lyme Borreliosis in Europe and North America, a team of authors whose expertise spans basic research, epidemiology, and clinical practice has compiled evidence–based information on Lyme borreliosis.
Presents all the latest evidence needed to diagnose, treat, and prevent Lyme disease
Lyme Borreliosis in Europe and North America begins with a review of the disease′s epidemiology, the causative Borrelia genospecies, and tick vectors. It then explores pathogenesis, diagnosis, and treatment. Next, the book examines the role of serologic, culture, and molecular diagnostic methods. The book also features a chapter on prognosis, offering an evidence–based review of outcome studies, as well as practical advice to physicians to help them manage the challenging clinical scenario of chronic symptoms attributed to Borrelia infection. The final chapter is a guide to prevention strategies, including the management of tick bites.
Examines similarities and differences in Europe and North America
Because differences in Borrelia genospecies are responsible for differences in the clinical presentation of Lyme borreliosis between North America and Europe, this book provides descriptions of the disease as it presents on each continent. Most of the chapters have been cowritten by experts on each continent, in order to provide a balanced perspective that combines European and North American findings, practices, and experiences.
Helps everyone better understand, treat, and control Lyme disease
Lyme Borreliosis in Europe and North America is a comprehensive reference, ideal for clinicians, researchers, and public health officials who seek to treat and control Lyme borreliosis. It will help them better understand the facts and make sense of the misconceptions and myths that surround this infectious disease.
1 THE EMERGENCE AND EPIDEMIOLOGY OF LYME BORRELIOSIS IN EUROPE AND NORTH AMERICA 1
Sunil K. Sood, Susan O′Connell, and Klaus Weber
2 THE SPIROCHETES AND VECTOR TICKS OF LYME BORRELIOSIS IN NATURE 37
Joseph Piesman and Pierre–Francois Humair
3 EARLY LYME BORRELIOSIS 53
Vijay K. Sikand and Robert R. Mu¨llegger
4 LYME CARDITIS 81
Fadi A. Haddad and Sunil K. Sood
5 NERVOUS SYSTEM LYME BORRELIOSIS 93
John J. Halperin and Leif Dotevall
6 LYME ARTHRITIS 115
Frank Dressler, Patricia I. Irigoyen, Norman T. Ilowite, and Hans–Iko Huppertz
7 BORRELIAL LYMPHOCYTOMA AND ACRODERMATITIS CHRONICA ATROPHICANS 135
Mark B. Salzman and Robert R. Mullegger
8 LYME BORRELIOSIS COINFECTIONS WITH ANAPLASMA AND BABESIA 149
Paul M. Lantos and Peter J. Krause
9 THE ROLE OF CULTURE AND NUCLEIC ACID AMPLIFICATION IN DIAGNOSIS OF LYME BORRELIOSIS 159
Gary P. Wormser and Guiqing Wang
10 SERODIAGNOSIS OF LYME BORRELIOSIS 185
Barbara J. B. Johnson, Maria E. Aguero–Rosenfeld, and Bettina Wilske
11 PROGNOSIS OF PERSONS WITH LYME BORRELIOSIS 213
Eugene D. Shapiro and Sunil K. Sood
12 PREVENTION OF LYME BORRELIOSIS 225
Sunil K. Sood