While considerable advances have been made on pharmacotherapies for many chronic disease states, options available to treat chronic pain have remained relatively unchanged for decades. However, utilizing the receptors involved in peripheral pain transduction mechanisms offers a significant opportunity to create novel therapies for pain.
A comprehensive review of peripheral pain mechanisms, Peripheral Receptor Targets for Analgesia: Novel Approaches to Pain Management provides a unique resource that brings together a body of knowledge that was previously widely dispersed. As such, it gives readers a framework for further basic and clinical studies on potential receptor targets, as well as the development of improved topical analgesics.
The latest discoveries by leading researchers relating to the function of various ion channels and receptors in the peripheral nervous system
Novel delivery techniques
An appendix listing currently available topical analgesic medications
A Foreword by Professor Lars Arendt-Nielsen of the Center for Sensory-Motor Interaction (SMI) at Aalborg University
An unmatched resource for improving drug therapies and making pain management more efficient, Peripheral Receptor Targets for Analgesia supplies pharmaceutical scientists, pharmacologists, neuroscientists, and graduate and upper-level undergraduate students with a comprehensive, up-to-date reference.
PART I PERIPHERAL MECHANISM IN CLINICAL PAIN CONDITIONS.
1. Role of Peripheral Mechanisms in Craniofacial Pain Conditions (Barry J. Sessle).
2. Role of Peripheral Mechanisms in Spinal Pain Conditions (Brian E. Cairns and Pradit Prateepavanich).
PART II SPECIFIC RECEPTOR TARGETS FOR PERIPHERAL ANALGESICS.
3. Voltage-Gated Sodium Channels in Peripheral Nociceptive Neurons as Targets For the Treatment of Pain (Theodore R. Cummins).
4. Potassium Channels (Daisuke Nishizawa1, Toru Kobayashi, and Kazutaka Ikeda).
5. Voltage-Gated Calcium Channels as Targets for the Treatment of Chronic Pain (Joe McGivern).
6. Adenosine Receptors (Jana Sawynok).
7. Acid-Sensing Ion Channels and Pain (Roxanne Y. Walder, Christopher J. Benson and Kathleen A. Sluka).
8. Vanilloid (TRPV1) and Other Transient Receptor Potential Channels (Marcello Trevisani and Arpad Szallasi).
9. Glutamate Receptors (Brian E. Cairns).
10. Serotonin Receptors (Malin Ernberg).
11. Adrenergic Receptors (Antti Pertovaara).
12. Cholinergic Receptors and Botulinum Toxin (Parisa Gazerani).
13. Cannabinoids and Pain Control in the Periphery (Jason J. McDougall).
14. Opioid Receptors (Claudia Herrera Tambeli, Luana Fischer and Carlos Amilcar Parada).
15. Calcitonin Gene-Related Peptide and Substance P (Ranjinidevi Ambalavanar and Dean Dessem).
16. Role of Somatostatin and Somatostatin Receptors in Pain (Ujendra Kumar).
17. Cytokines (Tumor Necrosis Factor, Interleukins) and Prostaglandins (Per Alstergren).
18. Neurotrophic Factors and Pain (Peter Svensson).
PART III DELIVERY SYSTEMS.
19. Topical and Systemic Drug Delivery Systems Targeted Drug Therapy (Urs Hafeli and Amit Kale).
20. Gene Therapy for Pain (Marina Mata and David J. Fink).
21. Topical Analgesics (Akhlaq Waheed Hakim and Brian E. Cairns).