Transcription Factors. Normal and Malignant Development of Blood Cells

  • ID: 2172675
  • Book
  • 640 Pages
  • John Wiley and Sons Ltd
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Transcription Factors

Normal and Malignant Development of Blood Cells

Katya Ravid and Jonathan Licht

The role of transcription factors in activating specific genes in blood cells is an important facet of hematopoiesis. Equally important, however, is the pursuit of genes rearranged and aberrantly activated in leukemias (blood malignancies). Transcription Factors: Normal and Malignant Development of Blood Cells focuses on those major transcription factors involved in activation of lineage–specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the identification and characterization of chromosomal rearrangement in human blood leukemias.

This complete digest of current transcription factor data offers comprehensive coverage of the myriad of transcription factors in blood cell development, composed by established experts in the field. In addition to updating the reader on the connection between chromosomal translocations involving transcription factors and cellular transformation leading to leukemia, Transcription Factors also reviews such subjects as:

∗ Transcription factors and the megakaryocytic, myeloid, and erythroid lineages

∗ Leukemias due to chromosomal translocations involving gene encoding transcription factors

∗ Oncogenesis and hematopoiesis

∗ In vivo studies of transcription factors implicated in hematopoiesis

∗ And much more

Appealing to both the researcher and the clinician in the field of hematology, Transcription Factors is a timely presentation of cell lineage development and sheds light on the processes involved in the development of specific leukemias. Providing insight into the study of transcription factors, readers will gain an understanding of mechanisms that lead to normal lineage commitment and terminal differentiation.
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Partial table of contents: INTRODUCTORY CHAPTER.

Transcription Factors in Normal and Malignant Hematopoiesis: An Overview (K. Ravid & J. Licht).

TRANSCRIPTION FACTORS AND THE MEGAKARYOCYTIC AND ERYTHROID LINEAGES.

The Role of GATA–1 and FOG in Erythroid and Megakaryocytic Differentiation (A. Tsang, et al.).

Regulation of Megakaryocyte and Erythroid Differentiation by NF–E2 (S.–W. Kim & R. Shivdasani).

EKLF and the Development of the Erythroid Lineage (J. Bieker).

TRANSCRIPTION FACTORS AND THE MYELOID LINEAGE.

CBFA2(AML1) and CBFB: Genes Required for the Development of All Definitive Hematopoietic Lineages (N. Speck & E. Dzierzak).

PU.1 and the Development of the Myeloid Lineage (D. Tenen).

Transcriptional Targets of the Vitamin D3 Receptor During Myeloid Cell Differentiation (V. Bromleigh, et al.).

TRANSCRIPTION FACTORS AND THE LYMPHOID LINEAGE.

The Role of Ikaros–Family Genes in Lymphocyte Differentiation and Proliferation (N. Avitahl, et al.).

The Role of PU.1 in B–Lymphocyte Development and Function (S. Rao & M. Simon).

The Role of Octamer Transcription Factors in the Lymphoid System (E. Bertolino, et al.).

The Role of Early B–Cell Factor in B Lymphocyte Development (M. Sigvardsson).

LEUKEMIAS DUE TO CHROMOSOMAL TRANSLOCATIONS INVOLVING GENES ENCODING TRANSCRIPTION FACTORS.

The Role of RAR and its Fusion Partners in Acute Promyelocytic Leukemia (A. Melnick & J. Licht).

The Leukemogenic Function of the Inv(16) Fusion Gene CBFB–MYH11 (P. Liu, et al.).

The TEL–AML–1 Translocation (G. Gilliland & T. Golub).

The Acetyltransferases CBP and p300: Molecular Integrators of Hematopoietic Transcription Involved in Chromosomal Translocations (G. Blobel).

ONCOGENESIS AND HEMATOPOIESIS.

The Roles of the C–Myc and B–Myb Oncogenes in Hematopoiesis and Leukemogenesis (M. Arsura & G. Sonenshein).

SUMMARY OF TRANSCRIPTION FACTORS IMPLICATED IN HEMATOPOIESIS: IN VIVO STUDIES.

Transcription Factors Implicated in Hematopoiesis: In Vivo Studies (Y. Kaluzhny & K. Ravid).
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"The researchers who work actively on these issues will find this book to be a source of discussion and references." (International Journal of Hematology, October 2001)
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