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Elements of Molecular Neurobiology. 3rd Edition

  • ID: 2172901
  • Book
  • 630 Pages
  • John Wiley and Sons Ltd
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From published reviews of the previous editions:

"This is one of those essential books that come along from time to time. It should be read by all biologists interested in the nervous system and especially by neuroscientists and pharmacologists." TIPS

"a timely and enjoyable introduction to molecular neurobiology." TINS

"This book is a triumph of clarity of thought, expression and presentation." BRAIN

"...provides an excellent primer, both to neuroscience students and researchers who want an introduction to molecular biology, and to molecular biologists who want an introduction to neuroscience." QUARTERLY REVIEW OF BIOLOGY

"A well–illustrated, well–written undergraduate text on neurobiology." HUMAN PSYCHOPHARMACOLOGY

"...an interesting, well–written text" THES

"Excellent starting point for the synthesis of structural elements." BIOCHIMIE

This thoroughly revised and updated new edition of C.U.M. Smith′s 1996 text gives an account of the molecular biology of the brain as it stands at the beginning of the twenty–first century.

While retaining the overall structure of the second edition, this new edition incorporates:

New material on

∗ genomics

∗ ion channels

∗ neural stem cells

∗ gap junctions

∗ channelopathies

∗ cannabinoids

∗ DNA–chips

∗ manipulation of K+–channels

∗ molecular bases of memory

∗ motor neuron disease (MND)

∗ Alzheimer′s Disease (AD)

∗ Greater emphasis throughout on the molecular bases of disease

∗ The most up–to–date neuropharmacology

∗ Fifty new and/or revised illustrations

∗ Extensive bibliographies, including relevant web–sites
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Preface to the First Edition.

Preface to the Second Edition.

Introductory Orientation.

The Conformation of Informational Macromolecules.

Information Processing in Cells.

Molecular Evolution.

Manipulating Biomolecules.



G–protein–coupled Receptors.


Ligand–gated Ion Channels.

Voltage–gated Channels.

Resting Potentials and Cable Conduction.

Sensory Transduction.

The Action Potential.

The Neuron as a Secretory Cell.

Neurotransmitters and Neuromodulators.

The Postsynaptic Cell.

Developmental Genetics of the Brain.

Epigenetics of the Brain.


Some Pathologies.

Appendix 1. Molecules and Consciousness.

Appendix 2. Units.

Appendix 3. Data.

Appendix 4. Genes.

Appendix 5. Physical Models of Ion Conduction and Gating.

Acronyms and Abbreviations.



Index of Neurological Disease.


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C. U. M. Smith
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