+ T–cell subset activities, biology of the CD–4
+ T–cell TH17 subset and regulatory T–cell, cross–presentation, mechanisms of tolerance induction, immunoediting and tumor camouflage and the connection between inflammation and cancer development, immunogenetics of primary immunodeficiencies and the immunology of HIV infections and AIDS, and vaccines; and more all immersed in full–color artwork, design, and user–friendly text.
This Second Edition provides a completely up–to–date introduction to immunology through its careful investigation of:
Cells and organs of the human system
Antigens and antibodies
Antigen–antibody interactions and some experimental systems
Genetics of antibody formation and structure
The major histocompatibility complex and development of immunity
T–cell receptor complex
Immunologic tolerance and autoimmunity
Immunity to microbes
Successfully blending biology, clinical science, genetics, and molecular biology, this book represents a complete account of our knowledge of immunology. It is complemented with a number of pedagogical aids that assist readers in the learning process, including chapter outlines, objectives, mini–summaries that provide "mental breathers" within the chapter to reassess the material just covered, full–chapter summaries, figures, and a self–evaluation section. The book ends with anextensive glossary and an appendix. It serves as an excellent textbook for courses in the life and medical sciences at the upper–undergraduate and graduate levels and as a reference for practicing scientists and clinical researchers.
Note to Reader.
1. Introduction to the Immune System.
2. Cells and Organs of the Immune System.
3. Innate Immunity.
4. Antigens and Antibodies.
5. Antigen–Antibody Interactions and Some Experimental Systems.
6. The Genetics of Antibody Formation and Structure.
7. The Major Histocompatibility Complex and Development of Immunity.
8. The T–Cell Receptor Complex: Characterization, Diversification, Costimulatory Molecules, Thymic Selection, and T–Cell Activation.
10. Cellular Interactions: Development of Effector Functions and Their Regulation.
13. Immunologic Tolerance and Autoimmunity.
14. Transplantation Immunology.
15. Tumor Immunology.
17. Immunity to Microbes.
Glossary of Commonly Used Immunologic Terms.
Appendix: Human Cluster of Differentiation (CD) Molecules.