Centred around a set of nine case studies on the application of GEC to different areas of medicine, the book offers an overview of applications of GEC to medicine, describes applications in which GEC is used to analyze medical images and data sets, derive advanced models, and suggest diagnoses and treatments, finally providing hints about possible future advancements of genetic and evolutionary computation in medicine.
- Explores the rapidly growing area of genetic and evolutionary computation in context of its viable and exciting payoffs in the field of medical applications.
- Explains the underlying theory, typical applications and detailed implementation.
- Includes general sections about the applications of GEC to medicine and their expected future developments, as well as specific sections on applications of GEC to medical imaging, analysis of medical data sets, advanced modelling, diagnosis and treatment.
- Features a wide range of tables, illustrations diagrams and photographs.
List of Contributors.
2 Evolutionary Computation: A Brief Overview (Stefano Cagnoni and Leonardo Vanneschi).
2.2 Evolutionary Computation Paradigms.
2.2.1 Genetic Algorithms.
2.2.2 Evolution Strategies.
2.2.3 Evolutionary Programming.
2.2.4 Genetic Programming.
2.2.5 Other Evolutionary Techniques.
2.2.6 Theory of Evolutionary Algorithms.
3 A Review of Medical Applications of Genetic and Evolutionary Computation (Stephen L. Smith).
3.1 Medical Imaging and Signal Processing.
3.1.2 Image Segmentation.
3.1.3 Image Registration, Reconstruction and Correction.
3.1.4 Other Applications.
3.2 Data Mining Medical Data and Patient Records.
3.3 Clinical Expert Systems and Knowledge–based Systems.
3.4 Modelling and Simulation of Medical Processes.
3.5 Clinical Diagnosis and Therapy.
4 Applications of GEC in Medical Imaging.
4.1 Evolutionary Deformable Models for Medical Image Segmentation: A Genetic Algorithm Approach to Optimizing Learned, Intuitive, and Localized Medial–based Shape Deformation (Chris McIntosh and Ghassan Hamarneh).
184.108.40.206 Statistically Constrained Localized and Intuitive Deformations.
220.127.116.11 Genetic Algorithms.
18.104.22.168 Population Representation.
22.214.171.124 Encoding the Weights for GAs.
126.96.36.199 Mutations and Crossovers.
188.8.131.52 Calculating the Fitness of Members of the GA Population.
4.2 Feature Selection for the Classification of Microcalcifications in Digital Mammograms using Genetic Algorithms, Sequential Search and Class Separability (Santiago E. Conant–Pablos, Rolando R. Hernández–Cisneros, and Hugo Terashima–Marín).
184.108.40.206 Detection of Potential Microcalcifications (Signals).
220.127.116.11 Classification of Signals into Microcalcifications.
18.104.22.168 Detection of Microcalcification Clusters.
22.214.171.124 Classification of Microcalcification Clusters into Benign and Malignant.
4.2.3 Experiments and Results.
126.96.36.199 From Pre–processing to Signal Extraction.
188.8.131.52 Classification of Signals into Microcalcifications.
184.108.40.206 Microcalcification Clusters Detection and Classification.
4.2.4 Conclusions and Future Work.
4.3 Hybrid Detection of Features within the Retinal Fundus using a Genetic Algorithm (Vitoantonio Bevilacqua, Lucia Cariello, Simona Cambo, Domenico Daleno, and Giuseppe Mastronardi).
4.3.2 Acquisition and Processing of Retinal Fundus Images.
220.127.116.11 Retinal Image Acquisition.
18.104.22.168 Image Processing.
4.3.3 Previous Work.
22.214.171.124 Vasculature Extraction.
126.96.36.199 A Genetic Algorithm for Edge Extraction.
188.8.131.52 Skeletonization Process.
184.108.40.206 Experimental Results.
5 New Analysis of Medical Data Sets using GEC.
5.1 Analysis and Classification ofMammography Reports using Maximum Variation Sampling (Robert M. Patton, Barbara G. Beckerman, and Thomas E. Potok).
5.1.3 Related Works.
5.1.4 Maximum Variation Sampling.
5.1.7 Results & Discussion.
5.2 An Interactive Search for Rules in Medical Data using Multiobjective Evolutionary Algorithms (Daniela Zaharie, D. Lungeanu, and Flavia Zamfirache).
5.2.1 Medical Data Mining.
5.2.2 Measures for Evaluating the Rules Quality.
220.127.116.11 Accuracy Measures.
18.104.22.168 Comprehensibility Measures.
22.214.171.124 Interestingness Measures.
5.2.3 Evolutionary Approaches in Rules Mining.
5.2.4 An Interactive Multiobjective Evolutionary Algorithm for Rules Mining.
126.96.36.199 Rules Encoding.
188.8.131.52 Reproduction Operators.
184.108.40.206 Selection and Archiving.
220.127.116.11 User Guided Evolutionary Search.
5.2.5 Experiments in Medical Rules Mining.
18.104.22.168 Impact of User Interaction.
5.3 Genetic Programming for Exploring Medical Data using Visual Spaces (Julio J. Valdés, Alan J. Barton, and Robert Orchard).
5.3.2 Visual Spaces.
22.214.171.124 Visual Space Realization.
126.96.36.199 Visual Space Taxonomy.
188.8.131.52 Visual Space Geometries.
184.108.40.206 Visual Space Interpretation Taxonomy.
220.127.116.11 Visual Space Characteristics Examination.
18.104.22.168 Visual Space Mapping Taxonomy.
22.214.171.124 Visual Space Mapping Computation.
5.3.3 Experimental Settings.
126.96.36.199 Implicit Classical Algorithm Settings.
188.8.131.52 Explicit GEP Algorithm Settings.
5.3.4 Medical Examples.
184.108.40.206 Data Space Examples.
220.127.116.11 Semantic Space Examples.
5.3.5 Future Directions.
6 Advanced Modelling, Diagnosis and Treatment using GEC.
6.1 Objective Assessment of Visuo–spatial Ability using Implicit Context Representation Cartesian Genetic Programming (Michael A. Lones and Stephen L. Smith).
6.1.2 Evaluation of Visuo–spatial Ability.
6.1.3 Implicit Context Representation CGP.
18.104.22.168 Data Collection.
22.214.171.124 Parameter Settings.
6.2 Towards an Alternative to Magnetic Resonance Imaging for Vocal Tract Shape Measurement using the Principles of Evolution (David M. Howard, Andy M. Tyrrell, and Crispin Cooper).
6.2.2 Oral Tract Shape Evolution.
6.2.3 Recording the Target Vowels.
6.2.4 Evolving Oral Tract Shapes.
126.96.36.199 Oral Tract Areas.
188.8.131.52 Spectral Comparisons.
6.3 How Genetic Algorithms can Improve Pacemaker Efficiency (Laurent Dumas and Linda El Alaoui).
6.3.2 Modeling of the Electrical Activity of the Heart.
6.3.3 The Optimization Principles.
184.108.40.206 The Cost Function.
220.127.116.11 The Optimization Algorithm.
18.104.22.168 A New Genetic Algorithm with a Surrogate Model.
22.214.171.124 Results of AGA on Test Functions.
6.3.4 A Simplified Test Case for a Pacemaker Optimization.
126.96.36.199 Description of the Test Case.
188.8.131.52 Numerical Results.
7 The Future for Genetic and Evolutionary Computation in Medicine: Opportunities, Challenges and Rewards.
7.4 The Future for Genetic and Evolutionary Computation in Medicine.
Appendix: Introductory Books and Useful Links.